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Updated: Jun 28, 2025

Preparation of Oligomeric β-amyloid1-42 and Induction of Synaptic Plasticity Impairment on Hippocampal Slices
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对抗阿尔茨海默氏病的基甲基-氧沙醇化合物的设计和合成

Asaf E Evren1,2, Demokrat Nuha1,3, Begüm N S Özkan1

  • 1Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Anadolu University, Eskişehir, Turkey.

Archiv der Pharmazie
|April 24, 2024
PubMed
概括

这项研究开发了用于阿尔茨海默病治疗的新型化合物,显示出显著的乙胆酶抑制. 化合物7e对AChE和BACE-1都表现出有前途的活性,提供了潜在的治疗益处.

关键词:
一,三,四-氧化.胆化酶是一种胆化酶.分子对接的分子对接.分子动力学刺激刺激分子动力学的 β-分泌酶.

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