适度到晚期早产婴儿的营养支持 - 一个随机试验
Tanith Alexander1, Sharin Asadi1, Michael Meyer1
1From Liggins Institute (T.A., S.A., J.E.H., M. Muelbert, F.H.B.), the Department of Statistics, Faculty of Science (Y.J.), and the Department of Paediatrics, Child and Youth Health (J.M.A.), University of Auckland, and the Neonatal Unit, Kidz First, Middlemore Hospital, Te Whatu Ora Counties Manukau (T.A., M. Meyer), Auckland, and Newborn Services, Starship Child Health, Te Toka Tumai Auckland, Te Whatu Ora (J.M.A.) - all in New Zealand.
对于中度到晚期早产婴儿的常规营养干预措施没有影响到完全肠道养或身体组成的时间. 需要进一步的研究来优化对这些易受伤害的婴儿过渡到母乳的营养支持.
科学领域:
- 新生儿营养新生儿营养
- 儿科胃肠病学 儿科胃肠病学
- 临床试验研究临床试验研究
背景情况:
- 中期到晚期的早产婴儿在过渡到纯母乳养期间经常需要营养支持.
- 在这个人群中优化营养策略的基于证据的指南是有限的.
研究的目的:
- 评估特定营养干预措施在支持中度到晚期早产婴儿方面的有效性.
- 评估亲肠道营养,补充牛奶和感官暴露对婴儿养和身体组成的影响.
主要方法:
- 一个多中心的因子随机试验,涉及532名早产婴儿 (32-35周怀孕).
- 干预措施包括肠道营养与乳糖,补充牛奶与纯母乳养,口味/气味暴露与没有.
- 主要结局是4个月的身体脂肪百分比,调整年龄和完全肠道养的时间.
主要成果:
- 亲肠道营养和乳糖组之间的体脂百分比没有显著差异 (P=0.72).
- 纯母乳养和补充牛奶的群体在体脂百分比上也没有显著差异 (P=0.25).
- 婴儿与没有味道/气味接触的婴儿的全肠养时间相似 (P=0.59).
结论:
- 常规的营养干预措施,包括腹腔营养,补充牛奶和感官暴露,并没有显著影响早产婴儿的食结果或身体组成.
- 这些发现表明,目前的常规做法可能不会改变这一群体的关键发展里程碑.
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