气候变暖促进了蓝藻细菌的附带抗生素耐药性发展
Zhiyuan Wang1, Qiuwen Chen1, Jianyun Zhang2
1National Key Laboratory of Water Disaster Prevention, Nanjing Hydraulic Research Institute, Nanjing 210098, China; Center for Eco-Environment Research, Nanjing Hydraulic Research Institute, Nanjing 210098, China; Yangtze Institute for Conservation and Development, Hohai University, Nanjing 210098, China.
Water research
|April 24, 2024
概括
温度升高和抗生素混合物加速了蓝藻细菌的生长.
科学领域:
- 环境微生物学与公共卫生
背景情况:
- 蓝藻细菌的繁殖和抗生素耐药性正成为日益严重的全球威胁.
- 菌在水生环境中充当抗生素耐药性基因的储存库.
- 气候变化对蓝菌相关抗生素耐药性的影响尚不清楚.
研究的目的:
- 为了研究温度上升对蓝藻细菌相关抗生素耐药性演变的影响.
- 分析蓝藻细菌中的抗生素相互作用和附带敏感性.
- 了解温度和抗生素组合对耐药性发展的联合影响.
主要方法:
- 在600种蓝藻细菌菌株中对抗生素相互作用和附带敏感性网络的概述.
- 分析了来自中国四个环氧化湖的50个地点的33种抗生素.
- 量化温度和附带电阻对电阻演变的相互作用影响.
主要成果:
- 菌中的抗生素耐药性水平与抗生素异质性正相关.
- 附带耐药性是普遍存在的 (78.5%),扩大了突变选择窗口.
- 温度升高 (16°C至36°C) 显著提高了附带抗性信息的血统中的可进化性 (1.252.5折) 和基因型抗性 (3295折).
结论:
- 气候变暖,加上附带耐药性,加速了蓝菌相关抗生素耐药性的演变.
- 温度升高和抗生素切换促进了耐药性突变的出现.
- 研究结果提供了关于气候变化如何加剧水生生态系统中抗生素耐药性的机制性见解.
相关概念视频
Antibiotic Selection
53.3K
Overview
53.3K
Bioremediation
18.3K
Bioremediation is the use of prokaryotes, fungi, or plants to remove pollutants from the environment. This process has been used to remove harmful toxins in groundwater as a byproduct of agricultural run-off and also to clean up oil spills.
18.3K
Global Climate Change
24.3K
Throughout its ~4.5 billion year history, the Earth has experienced periods of warming and cooling. However, the current drastic increase in global temperatures is well outside of the Earth’s cyclic norms, and evidence for human-caused global climate change is compelling. Paleoclimatology, the study of ancient climate conditions, provides ample evidence for human-caused global climate change by comparing recent conditions with those in the past.
24.3K
Responses to Heat and Cold Stress
13.5K
Every organism has an optimum temperature range within which healthy growth and physiological functioning can occur. At the ends of this range, there will be a minimum and maximum temperature that interrupt biological processes.
13.5K
Adaptations that Reduce Water Loss
25.5K
Though evaporation from plant leaves drives transpiration, it also results in loss of water. Because water is critical for photosynthetic reactions and other cellular processes, evolutionary pressures on plants in different environments have driven the acquisition of adaptations that reduce water loss.
25.5K
Defense Against Bacterial Pathogens
1.4K
The human immune system is a complex network of cells, tissues, and organs that work together to defend the body against bacterial infections. It consists of various immune cells, each playing a specific role in the defense mechanism.
Phagocytes
Phagocytes are the frontline soldiers of the immune system. They include neutrophils and macrophages. Neutrophils are the most abundant type of white blood cell and are quickly mobilized to the site of infection. Macrophages are larger cells that patrol...
Phagocytes
Phagocytes are the frontline soldiers of the immune system. They include neutrophils and macrophages. Neutrophils are the most abundant type of white blood cell and are quickly mobilized to the site of infection. Macrophages are larger cells that patrol...
1.4K


