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Updated: May 5, 2026

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在大鼠中脊髓损伤后,谷氨对功能和组织学恢复的影响

Fernando Flores de Araujo1, Raphael Martus Marcon2, Alexandre Fogaça Cristante2

  • 1Instituto de Ortopedia e Traumatologia, Hospital das Clínicas, Faculdade de Medicina, Universidade de São Paulo (IOT-HCFMUSP), São Paulo, SP, Brazil.

Clinics (Sao Paulo, Brazil)
|April 24, 2024
PubMed
概括

谷氨 (GSH) 给药改善了脊髓损伤后大鼠的功能恢复和轴突再生. 这项研究表明GSH.

关键词:
抗氧化剂/药物影响中央神经系统/损伤葡萄糖氨酸 (Glutathione) 是一种它们是老鼠,老鼠,老鼠.脊髓损伤造成的伤害

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Early Ischemia and Ionic ImbalanceWithin minutes of spinal cord injury, a secondary cascade begins, progressing over hours to weeks. Vascular damage reduces blood flow, causing ischemia and mitochondrial dysfunction. ATP depletion leads to ion pump failure, membrane depolarization, sodium influx, potassium efflux, and water accumulation, resulting in cellular swelling. Increased intracellular calcium further disrupts mitochondria and accelerates cellular injury.Excitotoxicity and Neuronal...
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