海马作为一个结构和功能网络中心,是神经认知衰老中远程皮质稀释的中心
Charly Hugo Alexandre Billaud1, Junhong Yu1
1Nanyang Technological University, Psychology, School of Social Sciences, 48 Nanyang Avenue, Singapore City 639798, Singapore.
Neurobiology of aging
|April 24, 2024
概括
大脑连接,特别是与海马的结构和功能连接 (SC,FC),会影响老年人的皮质厚度. 被破坏的海马连接可能会导致广泛的皮质稀释和记忆力下降.
科学领域:
- 神经科学是一个神经科学.
- 神经成像是一种神经成像.
- 老龄化大脑研究研究
背景情况:
- 灰质 (GM) 和白质 (WM) 变化与衰老中的认知衰退有关.
- 大脑网络的改变,包括功能连接 (FC) 和结构连接 (SC),都与广泛的缩有关.
研究的目的:
- 研究海马SC和FC对大脑连接区域皮质厚度 (CT) 的影响.
- 为了确定与记忆相关的皮质稀释相关的SC和FC的特定模式.
主要方法:
- 利用来自阿尔茨海默病神经成像计划的419名参与者的数据 (平均年龄为73岁).
- 采用拉索回归来识别与记忆相关的皮质区域以及用于SC和静止状态FC分析的结构方程模型 (SEM).
- 在海马 (LHIP,RHIP) 和各种皮层区域之间检查了SC和FC.
主要成果:
- 海马SC显著预测CT在连接的temporopolar/rhinal和fusiform/parahippocampal区域.
- 增加的右海马FC与较大的左下顶CT相关,而增加的左海马FC与右下 fusiform/parahippocampal CT相关.
- 研究结果表明,海马体的SC和FC是区域皮层厚度的关键决定因素.
结论:
- 海马作为潜在的皮层稀释中心.
- 海马结构和功能连接的破坏可能是神经认知衰老中观察到的广泛皮质缩的基础.
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