埃勒斯·丹洛斯综合征在儿科患者中的耳鼻喉后果
Chloe Cottone1, Douglas Nanu2, Erin M Gawel1
1Jacobs School Medicine and Biomedical Sciences, University at Buffalo, Buffalo, NY, USA.
International journal of pediatric otorhinolaryngology
|April 24, 2024
概括
患有埃勒斯·丹洛斯综合征 (EDS) 的儿童面临更高的听力损失,过敏性鼻炎,鼻炎和阻塞性睡眠呼吸暂停 (OSA) 的风险. 儿科医生应监测EDS患者的这些ENT条件.
科学领域:
- 儿科耳鼻喉科 儿科耳鼻喉科
- 遗传学 是一个遗传学.
- 免疫学 免疫学 免疫学
背景情况:
- 埃勒斯·丹洛斯综合征 (EDS) 是一组遗传性结缔组织疾病.
- 皮肤过弹性,关节过敏,缩性痕和血管脆弱性是EDS的特征.
- 对于EDS,没有特定的耳鼻喉诊断标准.
研究的目的:
- 为了比较患有EDS的儿童与没有EDS的儿童的耳鼻喉疾病的患病率.
- 在儿科群体中识别与EDS相关的潜在的ENT相关健康风险.
- 为了告知临床警特定耳鼻喉学后果在EDS的儿童.
主要方法:
- 使用美国TriNetX协作网络进行回顾性图表审查.
- 根据ICD-10代码G47.33定义EDS队列;非EDS队列不包括EDS患者.
- 倾向性得分匹配 (年龄,性别,种族) 用于听力损失,中耳炎,过敏鼻炎,急性桃体炎,鼻炎和阻塞性睡眠呼吸暂停 (OSA) 的队列比较.
主要成果:
- 患有EDS的儿童出现听力损失 (2.04倍),过敏性鼻炎 (1.6倍),鼻炎 (1.52倍) 和阻塞性睡眠呼吸暂停 (OSA) (4.24倍) 的可能性显著增加.
- 相反,患有EDS的儿童患急性桃体炎的可能性较低 (0.71x).
- 两组之间没有观察到中耳炎发病风险的统计差异.
结论:
- 被诊断为EDS的儿童患有特定耳鼻喉病的风险较高,包括听力损失,过敏性鼻炎,鼻炎和OSA.
- 潜在的免疫功能障碍可能导致EDS患者的这些风险增加.
- 儿科耳鼻喉科医生必须保持对EDS儿童潜在的耳鼻喉并发症的高度认识.
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