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基于酸水泥/蒙特莫里隆尼特-胺硫酸盐的等级抗生素输送系统,具有药物释放通路

Lei Chen¹, Xiuying Lin², Min Wei²

¹School of Science, Xi'an University of Technology, Xi'an 710054, PR China; Shaanxi Province Key Laboratory of Corrosion and Protection, Xi'an University of Technology, Xi'an 710048, PR China.

Colloids and surfaces. B, Biointerfaces

|April 24, 2024

概括

在酸水泥 (CPC) 中的蒙莫里隆尼特-珍塔米辛 (MMT-GS) 改善了对骨感染的抗生素输送. 这种新的CPC/MMT-GS配方为骨科应用提供了持续释放,增强强度和更好的生物相容性.

科学领域:

生物材料科学生物材料科学
整形外科手术整形外科手术
药物输送系统药物输送系统

背景情况:

带有抗生素的酸水泥 (CPC) 显示为骨科药物输送有前途.
现有的CPC配方存在爆发性抗生素释放,低累积释放和低于最佳的机械性能等问题.

研究的目的:

开发一种新型的CPC配方,其中包含蒙莫里隆尼特-胺素 (MMT-GS),以克服传统CPC的局限性.
为了实现 Gentamicin (GS) 的受控,持续释放,以有效治疗骨感染和炎症.

主要方法:

蒙莫里隆尼特-珍塔米辛 (MMT-GS) 是使用溶液间隔法合成的.
在酸水泥 (CPC) 中加入MMT-GS,以制造CPC/MMT-GS复合材料.
评估了药物释放动力学,机械强度,抗菌活性和体内生物相容性.

主要成果:

在504小时内,CPC/MMT-GS具有高累积释放率 (94.1±2.8%) 和高度 (1183.05μg/ml) 的GS.
药物释放遵循一个三阶段的等级模型 (Korsmeyer-Peppas,零顺序,扩散-溶解).
CPC/MMT-GS表现出增强的压力强度 (51.33 ± 3.62 MPa),强大的长期抗菌活性,并促进骨质细胞增殖,具有优异的体内基因相容性.

结论:

CPC/MMT-GS有效地克服了CPC中抗生素的突发释放问题.
开发的材料提供了持续的 gentamicin 释放,改进的机械性能,以及出色的生物相容性.
CPC/MMT-GS具有治疗因细菌感染和炎症而复杂的骨缺陷的巨大潜力.

关键词:

抗菌性质抗菌性质在CPC/MMT-GS中使用.压力强度的压力强度是什么药物释放途径药物释放途径释放机制释放机制

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