肝炎E和腹膜功能障碍:病例系列和文献综述
Michael Westhoff1,2, Andres Arias1, Patric Litterst1
1Pneumology, Lungenklinik Hemer, Hemer, Germany.
Pneumologie (Stuttgart, Germany)
|April 24, 2024
概括
肝炎E病毒 (HEV) 感染与腹膜功能障碍有关,这是一种影响呼吸的疾病. 这项研究发现了13例,这表明许多HEV相关病例未被诊断出来,特别是没有神经性肌缩症状的病例.
科学领域:
- 神经学 神经学
- 传染性疾病 传染性疾病
- 肺部病理学 肺部病理学
背景情况:
- 隔膜有多种不同的原因.
- 神经性缩 (NA) 与肝炎E病毒 (HEV) 感染有关.
- 隔膜功能障碍和HEV感染的患病率需要进一步调查.
研究的目的:
- 调查腹膜功能障碍患者中HEV感染的患病率.
- 探索HEV感染和神经性肌缩 (NA) 之间的关联.
- 为了确定HEV感染是否是被诊断不足的隔膜功能障碍的原因.
主要方法:
- 患有腹膜功能障碍和/或急性或过去的NA症状的患者在2020年7月至2023年8月期间接受了HEV感染查.
- 诊断方法包括临床评估,针对HEV IgG和IgM的免疫块检测,以及基因型分析.
- 共有13名患者被诊断患有腹膜功能障碍和HEV感染.
主要成果:
- 13名患者 (4名女性,9名男性,平均年龄59岁) 被诊断出腹膜功能障碍和HEV感染.
- 所有患者的肝脏值正常;诊断的中位延迟时间为5个月.
- 在所有病例中都发现了HEV基因型3,在8名具有高IgG标位的患者中也检测到了1型基因型.
结论:
- HEV感染是导致隔膜功能障碍的潜在原因,可能是一种仅涉及神经的NA形式.
- 这项研究表明,人口中存在大量未被检测到的HEV相关的隔膜功能障碍病例.
- 在隔膜功能障碍的情况下,即使没有典型的NA症状,也应该考虑HEV感染;抗病毒治疗值得讨论.
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