甲状腺癌和内分泌干扰化学物质:对 perfluoroalkyl 物质和其他持久有机污染物的病例对照研究
Valentina Cirello1,2, Marina Lugaresi3, Claudia Moneta3
1Department of Endocrine and Metabolic Diseases, Istituto Auxologico Italiano IRCCS, Milan, Italy.
European thyroid journal
|April 24, 2024
概括
这项研究发现,某些和多醇基物质 (PFAS) 和多二 (PCB) 与甲状腺癌 (TC) 有关. 然而,这些污染物的混合物与TC呈现反向相关性,可能是由于反向因果关系.
科学领域:
- 环境健康 环境健康
- 在瘤学瘤学.
- 内分泌学 在内分泌学.
背景情况:
- 内分泌干扰化学物质 (EDC) 是越来越令人担忧的环境污染物.
- 甲状腺癌 (TC) 发病率在全球范围内不断上升,促使人们对其原因进行研究.
- 特定的EDCs,如per-和多醇基物质 (PFAS) 和多双 (PCB) 在甲状腺癌发生中的作用需要进一步研究.
研究的目的:
- 调查特定的PFAS,PCB和二二三乙烯 (DDT) 的血清水平与甲状腺癌 (TC) 风险之间的关联.
- 探索这些环境污染物与TC的临床或分子特征之间的关系,包括BRAFV600E突变.
- 用混合模型评估这些污染物对TC风险的综合影响.
主要方法:
- 一个病例控制研究,包括112名TC患者和112名匹配的对照.
- 使用染色体质谱测量测量了PFAS (PFDA,PFHxS,PFNA,PFOS),PCB (PCB-105,PCB-118,PCB-153,PCB-138,PCB-180) 和DDT代谢物的血清度.
- 统计分析包括无条件后勤回归,贝叶斯核机器回归和加权量子和模型.
主要成果:
- perfluorodecanoic 酸 (PFDA) 显示与TC风险 (OR=2.03) 有积极的关联.
- perfluorohexanesulfonic acid (PFHxS) 与TC风险 (OR=0.63) 呈现出负相关性.
- 特定的PCB与更大,更具侵略性的瘤有关,而某些PFAS与较不具有侵略性的TC和特定的分子标记物 (如BRAF V600E突变) 相相关.
结论:
- 这项研究提供了新的证据,将某些PFAS和PCB与甲状腺癌及其病例控制环境中的特征联系起来.
- 在污染物和TC混合物之间观察到反向关联,这可能表明反向因果关系.
- 需要进一步的研究来阐明环境污染物和甲状腺癌发展之间的复杂相互作用.
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