配方参数对自我组装脂质体 (LeciPlex® III) 的影响:详细调查
Saurabh Katawale1, Shivali Tank2, Harshali Dhaygude1
1Department of Pharmaceutics, Bombay College of Pharmacy, Kalina, Santacruz, Mumbai 400 098, India.
International journal of pharmaceutics
|April 24, 2024
概括
这项研究探讨了使用大豆酸丁胆和各种稳定剂来创建LeciPlex®纳米载体. 配方调整显著影响了颗粒大小,使得各种纳米载体系统成为可能.
科学领域:
- 纳米技术纳米技术
- 材料科学 材料科学 材料科学
- 物理化学 物理化学
背景情况:
- 脂质体是重要的脂基囊泡纳米载体.
- 控制脂质体特征是它们应用的关键.
- 稳定剂在纳米载体配方中起着至关重要的作用.
研究的目的:
- 为了研究自组装LeciPlex®纳米载体的制造.
- 评估阴离子,阴离子和无离子稳定剂对LeciPlex®的影响.
- 探索影响囊泡自我组装的配方变量.
主要方法:
- 通过溶剂扩散技术进行纳米沉.
- 利用大豆酸胆作为主要的脂.
- 在LeciPlex®制造中使用了各种稳定剂 (离子,离子,非离子).
主要成果:
- 颗粒大小在所有系统中都与脂度有直接相关性.
- 溶剂和稳定剂类型显著影响了颗粒大小.
- 特定的脂:稳定剂比率 (2:1) 有利于带有离子/非稳定剂的囊泡系统,而阴离子稳定剂 (DODAB) 在两种比率 (1:2和2:1) 形成囊泡.
- 小角度中子散射和光学传导性证实了状和囊状结构.
结论:
- 多种稳定剂的添加显著扩大了LeciPlex®纳米载体的配方可能性.
- 定制配方参数允许控制自组装到所需的纳米结构.
- 这项研究为开发定制的脂基纳米载体提供了基础.
相关概念视频
Factors Influencing Drug Absorption: Pharmaceutical Parameters
133
Solid dosage forms such as tablets and capsules undergo rigorous manufacturing processes to ensure stability and effectiveness. Their dissolution and absorption properties are influenced significantly by the choice of excipients (inactive ingredients that serve various roles in the formulation), and the methodology applied during production. The manufacturing parameters, such as compression force and granulation techniques, significantly affect dissolution rates. Elevated compression forces...
133
Factors Affecting Dissolution: Drug pKa, Lipophilicity and GI pH
1.3K
Drug absorption within the gastrointestinal (GI) tract is a complex process influenced by several critical factors, including the site pH, the drug's dissociation constant (pKa), and the drug's lipophilicity. The GI tract exhibits a pH gradient, with an acidic environment in the stomach and a more alkaline environment in the small intestine. This pH variation directly affects the ionization state of drugs.
A drug's pKa and the pH of the gastrointestinal (GI) tract play crucial roles...
A drug's pKa and the pH of the gastrointestinal (GI) tract play crucial roles...
1.3K


