在患有低值躁狂的抑郁青少年中明显的全球大脑连接性改变以及与处理速度的关系:sBEAD队列的证据
Xiaofei Zhang1, Xiaofang Cheng2, Jianshan Chen2
1Department of Child and Adolescent Psychiatry, Affiliated Brain Hospital of Guangzhou Medical University, Guangzhou, Guangdong province 510300, PR China; The First School of Clinical Medicine, Southern Medical University, Guangzhou, Guangdong province 510000, PR China.
Journal of affective disorders
|April 24, 2024
概括
患有下值双极性障碍 (BD) 的青少年表现出明显的脑连接模式和较慢的处理速度. 这些神经成像发现有助于早期识别和干预BD.
科学领域:
- 神经成像是一种神经成像.
- 青少年精神病学 青少年精神病学
- 图形理论 图形理论
背景情况:
- 双极性障碍 (BD) 是一种需要早期识别的渐进性疾病.
- 抑郁青少年的下值躁狂 (SubMD) 可能表明早期的BD.
- 神经成像机制和 SubMD 的处理速度尚未得到充分理解.
研究的目的:
- 在患有下值躁狂的青少年中调查全球大脑连接 (GBC) 模式 (SubMD).
- 在完全出现BD之前,检查 SubMD患者的GBC和处理速度之间的关系.
- 识别潜在的神经成像生物标志物用于早期BD检测.
主要方法:
- 与72名SubMD,77名没有下值躁狂的抑郁青少年 (nSubMD) 和69名健康对照 (HC) 相比.
- 利用基于voxel的GBC地图的图形理论分析.
- 通过使用Trail Making Test Part A (TMT-A) 评估的处理速度.
主要成果:
- 亚MD患者表现出独特的GBC模式,与HC和nSubMD相比,右SFGmed/SFG的连接性降低,右Precuneus和左Postcentral Gyrus的连接性增加.
- 在SubMD和nSubMD两组中,GBC在右下椎中增加.
- 在SFGmed/SFG中的GBC与SubMD组的TMT-A得分正相关,表明处理速度受损.
结论:
- 患有下值BD的青少年表现出特定的全球大脑连接性改变.
- 这些连接模式与处理速度受损有关.
- 这些发现为双相情感障碍的早期识别和干预策略提供了洞察力.
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