摩亚莫亚病老年患者中风事件和危险因素
Yudai Hirano1, Satoru Miyawaki1, Hideaki Imai2
1Department of Neurosurgery, Faculty of Medicine, The University of Tokyo, Tokyo, Japan.
World neurosurgery
|April 24, 2024
概括
血液事件是老年人患有莫亚莫亚病 (MMD) 的主要问题. 前胸腔动脉扩张和胸腔解剖预测无症状病例的新出血.
科学领域:
- 神经学 神经学
- 血管神经学 血管神经学
- 流行病学 流行病学
背景情况:
- 莫亚莫亚病 (MMD) 是一种罕见的脑血管疾病.
- 了解老年人 (≥60岁) 的MMD需要具体的流行病学和临床分析.
研究的目的:
- 分析流行病学,自然史,中风事件,风险因素以及老年MMD患者的RNF213 p.Arg4810Lys变异.
- 在这个人口群体中确定中风事件的预测因素.
主要方法:
- 从2000年到2023年对MMD患者 (≥60岁) 的回顾性分析.
- 调查基线特征,发病类型,放射性特征和RNF213变体状态.
- 随访无症状半球以确定随后的中风事件.
主要成果:
- 在56名患者中,62个半球无症状,26个半球缺血发作,12个半球出血发作.
- 出血发作与前胸动脉 (AchA) 扩张和更糟糕的结果相关.
- 在无症状半球中,10人经历了随后的中风 (8次出血,2次缺血),由AchA扩张和胆道瘤预测.
结论:
- 在老年MMD患者 (≥60岁) 中,出血事件是最常见和预后显著的.
- 在老年MMD患者中,AchA扩张和冠状腺缩预测了无症状,非手术半球的新出血.
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