用手持紫外线装置在一秒钟内消毒导管的无针连接器
Michael Fourkas1, Eri Takami1, Gregory J Schears2
1PuraCath Medical Inc., Newark, CA.
American journal of infection control
|April 24, 2024
概括
紫外线C (UV-C) 光在一秒钟内有效消毒无针连接器 (NC),提供了一种潜在的新方法来减少中央线路相关的血液感染 (CLABSI). 这种快速消毒覆盖了内部和外部NC表面.
科学领域:
- 微生物学 微生物学
- 传染性疾病 传染性疾病
- 生物医学工程 生物医学工程
背景情况:
- 中枢静脉导管无针连接器 (NCs) 的标准消毒包括酒精或,但可能无法完全消毒内部表面.
- 中枢线相关血流感染 (CLABSI) 带来了重大的临床和经济负担,使其预防成为公共卫生优先事项.
- 紫外线C (UV-C) 光呈现了一种用于消毒内部和外部NC表面的新策略.
研究的目的:
- 评估一款用于消毒无针连接器 (NC) 的新型手持UV-C光装置的有效性.
- 为了比较UV-C光的消毒能力与NCs的标准护理.
- 评估UV-C消毒在减少中线相关血流感染 (CLABSI) 的潜力.
主要方法:
- 在临床上相关的细菌 (金黄色葡萄球菌,上皮葡萄球菌,大肠杆菌,Pseudomonas aeruginosa) 和Candida albicans被接种在NC上.
- 使用专有手持UV-C设备 (285nm,48mW/cm2) 在UV-C透明NC上测量消毒效果,暴露时间为1秒.
- 比较包括标准的消毒方法,如酒精盖,用于Staphylococcus aureus注射的NCs.
主要成果:
- 在UV-C暴露1秒后,对于临床相关的病原体,在UV-C透明NC的内部和外部表面观察到殖民地形成单位 (CFU) 的4日志减少.
- 紫外线光显示了内部和外部NC表面的有效消毒.
结论:
- 使用测试设备在一秒钟内对NC进行UV-C光消毒,在实验室研究中是有效的.
- 这种UV-C装置显示出作为一种减少CLABSI率的工具的希望.
- 计划进行进一步的临床研究,以在患者护理环境中验证这些发现.
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