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在高血糖的情况下,GMFB的SUMOylation调节了其在视网膜色素上皮细胞中的稳定性和功能

Wan Sun1, Juan Wang2, Caiying Liu1

  • 1Department of Ophthalmology of Shanghai Tongji Hospital and Laboratory of Clinical Visual Science of Tongji Eye Institute, Tongji University, Shanghai 200065, China; Department of Biochemistry and Molecular Biology, School of Medicine, Tongji University, Shanghai 200065, China.

International journal of biological macromolecules
|April 24, 2024
PubMed
概括

SUMO1对质成熟因子β (GMFB) 的SUMOylation增加了其稳定性,并影响了糖尿病期间视网膜细胞的信号传递. 这表明SUMOylated GMFB是糖尿病视网膜病变的潜在治疗点.

关键词:
膠質成熟因子-β (GMFB) 的使用过高血糖症的发生.蛋白质的稳定性 蛋白质的稳定性视网膜色素上皮细胞 视网膜色素上皮细胞这就是SUMOylation的作用.

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