哺乳期母亲低蛋白饮食对后代的跨代影响
Lin-Jian Gu1, Li Li2, Qian-Nan Li3
1State Key Laboratory of Stem Cell and Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing 100101, China; University of Chinese Academy of Sciences, Beijing 100049, China.
Journal of genetics and genomics = Yi chuan xue bao
|April 24, 2024
概括
哺乳期母亲的低蛋白饮食 (LPD) 影响子女的健康和生殖能力. 卵细胞的表观遗传变化可能会调解这些跨代效应.
科学领域:
- 生殖生物学 生殖生物学
- 发育生物学是发展生物学.
- 营养科学 营养科学
背景情况:
- 母亲的饮食和生活方式显著影响后代的健康.
- 环境因素及其机制的跨代影响尚未得到充分理解.
研究的目的:
- 研究母乳养期低蛋白饮食 (LPD) 对后代健康和生殖能力的跨代影响.
- 探索潜在的表观遗传机制,特别是卵细胞.
主要方法:
- 使用了一种小鼠模型,母乳哺乳期低蛋白饮食 (LPD).
- 分析后代的生存,生长,生殖参数 (排卵, litter 尺寸),肠道微生物组,卵细胞转录组和卵细胞甲基组.
- 检查了两代 (F1和F2后代) 的影响.
主要成果:
- 哺乳期母亲的LPD导致女性后代的生存率降低,生长迟缓,排卵减少, litter 尺寸更小 (F1).
- 在F1后代中观察到肠道微生物组和卵细胞转录组 (在怀孕和代谢基因中丰富) 的显著变化.
- 代谢健康受损和生长迟缓至少传给了F2一代.
- 在F1卵细胞的表观遗传变化 (甲基组变化) 被部分传播到F2卵细胞.
结论:
- 哺乳期母亲的LPD对后代的健康和生殖有不利的跨代影响.
- 这些效应很可能是由卵细胞的表观遗传修饰介导的,影响与新陈代谢和繁殖有关的基因表达.
- 该研究强调了母乳养期间母乳营养在规划跨代长期健康中的关键作用.
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