在COVID-19中使用心脏生物标志物的风险分层和预后预测:单中心回顾性队列研究
Madoka Sano1, Toshiaki Toyota2, Takeshi Morimoto3
1Department of Cardiovascular Medicine, Kobe City Medical Center General Hospital, Kobe, Japan.
BMJ open
|April 24, 2024
概括
心脏生物标志物如hsTnI和NT-proBNP的升高表明COVID-19患者死亡风险较高. 这些标记物可以帮助分层患者的风险,并指导临床决策以获得更好的结果.
科学领域:
- 心脏病学 心脏病学
- 传染性疾病 传染性疾病
- 生物标志物 生物标志物
背景情况:
- 由于COVID-19具有重大风险,因此需要用于患者风险分层的工具.
- 心脏生物标志物越来越多地因其在各种严重疾病中的预后潜力而得到认可.
研究的目的:
- 评估心脏生物标志物在住院COVID-19患者中分层风险的预后价值.
- 评估特定心脏生物标志物与COVID-19所有原因死亡率之间的关联.
主要方法:
- 一项回顾性队列研究包括917名COVID-19患者.
- 测量了心脏生物标志物,包括高灵敏度的素I (hsTnI),N终端亲B型尿素 (NT-proBNP),肌酸酶 (CK) 和CK心肌带 (CK-MB).
- 患者根据临床相关的值进行了分层,主要结局是30天的所有原因死亡.
主要成果:
- 高水平的hsTnI,NT-proBNP,CK和CK-MB与所有死因的30天累计发病率的增加显著相关.
- 每个生物标志物的特定值表明了与死亡风险的剂量依赖关系.
- 经过调整后的分析证实了心脏生物标志物升高与死亡风险增加之间的显著关联.
结论:
- 心脏生物标志物的升高是COVID-19患者预后不佳的重要指标.
- 心脏生物标志物可以作为COVID-19管理中的风险分层的宝贵工具.
- 进一步的研究可能会探索将这些生物标志物整合到临床决策算法中.
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