教育,而不是杀死:治疗癌症而不触发其防御系统.
Aneta Škarková1, Mariano Bizzarri2, Radoslav Janoštiak3
1Department of Cell Biology, BIOCEV, Faculty of Science, Charles University, Vestec, Czech Republic.
Trends in molecular medicine
|April 24, 2024
概括
传统的癌症疗法杀死细胞,促进抵抗力. 新的策略旨在重新教育癌细胞,使其变得不那么恶性,从而可能防止治疗耐药性和瘤进展.
科学领域:
- 在瘤学瘤学.
- 癌症生物学 癌症生物学
- 治疗开发的治疗方法
背景情况:
- 传统的抗癌治疗侧重于抑制癌细胞增殖.
- 细胞毒性疗法诱导选择性压力,有利于耐药癌细胞群的生存.
- 这种抗药性是瘤进展和治疗失败的主要原因.
研究的目的:
- 提出针对癌症特征的新型治疗策略,以超越扩散.
- 探索重新教育癌细胞,使其转向一种不那么恶性表型的方法.
- 为了规避瘤中适应性耐药性的发展.
主要方法:
- 针对癌细胞休眠状态.
- 使用转差疗法.
- 正常化瘤的微环境.
- 使用迁移性疗法.
主要成果:
- 建议的策略旨在改变癌细胞表型,而不是根除细胞.
- 对这些"教育"策略的适应性抵抗并不能提供增殖优势.
- 不耐药细胞不会被消除,从而保留了不那么具有攻击性的细胞群.
结论:
- 针对非扩散性癌症特征的替代治疗策略提供了一个有希望的方法.
- 重新培养癌细胞可能会延迟或阻止耐治疗瘤的出现.
- 专注于表型可塑性而不是直接杀死可以克服治疗耐药性.
相关概念视频
Targeted Cancer Therapies
7.6K
The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against...
There are several types of targeted therapies against...
7.6K
Cancer Therapies
7.6K
Cancer therapies are various modes of treatment, such as surgery, radiation therapy, and chemotherapy that are administered to cancer patients.
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
7.6K
Tumor Immunotherapy
520
Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.
520
Treatment Resistant Cancers
3.3K
Cancer is the second leading cause of death in the United States. A cancer cell is genetically unstable and hence can mutate faster. They can also modify their microenvironment and escape immune surveillance. The difficulties in treating cancer are further compounded by the emergence of rapid resistance to anticancer drugs. The most common ways to attain resistance in cancer cells include alteration in drug transport and metabolism, modification of drug target, elevated DNA damage response, or...
3.3K
Cancer Vaccines
359
Cancer treatment vaccines are a rapidly evolving field that offers a promising approach to immunotherapy. Unlike traditional vaccines that prevent diseases, cancer treatment vaccines are designed to treat existing cancers by stimulating the immune system to recognize and attack cancer cells.
Cancer vaccines come in two categories: preventive (prophylactic) and treatment (active). Preventive vaccines, such as the Human Papillomavirus (HPV) vaccine, protect against viruses that cause certain...
Cancer vaccines come in two categories: preventive (prophylactic) and treatment (active). Preventive vaccines, such as the Human Papillomavirus (HPV) vaccine, protect against viruses that cause certain...
359
Combination Therapies and Personalized Medicine
4.9K
Combining two or more treatment methods increases the life span of cancer patients while reducing damage to vital organs or tissue from the overuse of a single treatment. Combination therapy also targets different cancer-inducing pathways, thus reducing the chances of developing resistance to treatment.
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...
4.9K


