代谢功能障碍相关的脂肪肝亚型中的动脉硬性进展:一个前性队列研究
Lei Liu1, Yufu Zhou2, Shuwen Deng1
1Health Management Center, The Third Xiangya Hospital, Central South University, No.138 Tongzipo Road, Yuelu District, Changsha, Hunan, 410013, China.
Nutrition, metabolism, and cardiovascular diseases : NMCD
|April 24, 2024
概括
与代谢功能障碍相关的脂肪肝疾病 (MAFLD),特别是糖尿病 (DM-MAFLD) 和瘦质MAFLD亚型,显著加快动脉硬性的进展. 这凸显了在MAFLD患者中有针对性的心血管疾病风险分层的需要.
科学领域:
- 心血管健康 心血管健康
- 代谢障碍 代谢障碍 代谢障碍
- 肝脏疾病 肝脏疾病
背景情况:
- 与代谢功能障碍相关的脂肪肝疾病 (MAFLD) 是一个日益严重的全球健康问题.
- 动脉硬是心血管疾病 (CVD) 风险的一个关键指标.
- 了解MAFLD亚型对动脉硬度的影响对于风险评估至关重要.
研究的目的:
- 调查MAFLD和动脉硬度进展之间的相关性.
- 为了确定哪些MAFLD亚型最显著地影响动脉硬的进展.
- 提供关于MAFLD分层心血管疾病风险查和监测的证据.
主要方法:
- 一项队列研究涉及12,129名参与者,在2012年至2020年期间进行了两次健康检查.
- 测量手臂脚脉冲波速度 (baPWV),以评估动脉硬度.
- 将参与者分为非MAFLD,超重/肥胖MAFLD (OW-MAFLD),瘦/正常体重MAFLD (瘦-MAFLD) 和糖尿病MAFLD (DM-MAFLD) 组.
主要成果:
- 在基线时,MAFLD在37.2%的参与者中存在.
- 与非MAFLD相比,在所有MAFLD亚型中观察到高的baPWV变化率和比例.
- DM-MAFLD显示动脉硬性进展率最高,其次是瘦肌MAFLD和OW-MAFLD.
结论:
- MAFLD与加速的动脉硬性进展显著相关.
- 糖尿病MAFLD和瘦肉MAFLD亚型对动脉硬度进展的风险最大.
- 对MAFLD患者心血管疾病风险的分层查和监测策略在临床上很重要.
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