2015年至2018年期间,来自高度复杂性机构的囊性纤维化儿童的肺功能和身体组成参数
Aura María Salazar-Solarte1, Laura Torres-Canchala2, Frank Carrera-Gil3
1Pediatrics Department, Hospital Universitario Fundación Valle del Lili, Cali, Colombia; Faculty of Health Sciences, Universidad Icesi, Cali, Colombia; Interdisciplinary Research Group in Epidemiology and Public Health, Universidad Libre, Seccional, Cali, Colombia.
Pediatrics and neonatology
|April 24, 2024
概括
在患有囊性纤维化的儿童中,尾骨肌肉质量比身体质量指数 (BMI) 更好地表明肺功能. 建议对这些患者进行全面的身体组成分析,并与BMI一起进行监测.
科学领域:
- 儿科 儿科 儿科
- 肺部病理学 肺部病理学
- 营养科学 营养科学
背景情况:
- 囊性纤维化 (CF) 患者的充足营养改善了生存率和肺功能.
- 身体质量指数 (BMI) 是CF肺功能的一个独立预测指标,但可能掩盖营养状况的变化.
研究的目的:
- 调查儿童CF患者肺功能和BMI与身体组成参数之间的相关性.
- 评估不同营养指标在预测患有CF的儿童肺功能方面的有效性.
主要方法:
- 对33名CF患者 (5-17岁) 的观察性,横截面,回顾性研究.
- 使用斯皮尔曼测试对FEV1 (强迫呼吸量1秒) 和BMI/身体组成参数 (生物电阻) 之间的相关性分析.
主要成果:
- 尾骨肌肉质量与FEV1 (p<0.001) 有正相关性 (p<0.001).
- 无脂肪质量的百分比 (p=0.006) 和相角 (p=0.001) 也与肺功能有正相关.
- 百分比脂肪质量与FEV1负相关 (p=0.007),而BMI和无脂肪质量指数没有显著的相关性 (p=0.085).
结论:
- 尾骨肌肉质量是儿童CF患者肺功能的一个比BMI更敏感的指标.
- 在CF的常规人体测量后续检查中,应该与BMI一起进行身体成分分析.
- 需要对更大的队列进行进一步的研究,以标准化CF管理中使用身体成分参数.
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