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氧化应激和FOXO-1关系在第三阶段牙周炎

Elif Selin Gurbuz^1,2, Zeliha Guney³, Sivge Kurgan¹

¹Faculty of Dentistry Department of Periodontology, Ankara University, Ankara, Turkey.

Clinical oral investigations

|April 24, 2024

概括

牙周炎增加了氧化应激标志物8-氧化氧化 (8-OHdG) 的含量,并降低了唾液中的保护性转录因子Forkhead Box-O1 (FOXO1). 较低的FOXO1表达与疾病严重程度相关,表明它是潜在的治疗点.

科学领域:

口腔生物学口腔生物学
免疫学免疫学免疫学
生物化学生物化学

背景情况:

牙周炎是一种慢性炎症性疾病,影响牙支结构.
氧化应激,以8-氧化瓜诺辛 (8-OHdG) 表示,在牙周组织破坏中起作用.
叉头盒-O1 (FOXO1) 是一个关键的转录因子,参与细胞平衡和抗氧化剂防御.

研究的目的:

在牙周炎患者中量化血清和唾液中8-OHdG和FOXO1水平.
调查这些标记物与临床牙周指标之间的关系.
探索FOXO1在牙周炎的发病和调节中的潜在作用.

主要方法:

与酶相关的免疫吸收试验 (ELISA) 用于测量唾液和血清中的8-OHdG和FOXO1水平.
评估了临床牙周参数,包括斑块指数 (PI),探针深度 (PD),探针出血 (BOP) 和临床附着水平 (CAL).
在健康个体和患有一般化III期B级和C级牙周炎的患者之间进行了比较分析.

主要成果:

与健康对照组相比,牙周炎患者的临床牙周指标显著增加.
牙周炎组的唾液8-OHdG水平显著升高,表明氧化应激较高.
在牙周炎组中,唾液FOXO1水平显著降低,在FOXO1,BOP和唾液8-OHdG之间观察到负相关性.

结论:

减少FOXO1的表达,这是抗氧化酶的关键转录因子,有助于牙周炎的组织破坏.
在牙周炎症中,FOXO1可能起到免疫调节器的作用.
向FOXO1是治疗牙周炎的潜在治疗策略,因为它在抗氧化剂防御中的作用.

关键词:

(MeSH):牙周炎是指牙周炎.8-氧化氧化瓜诺 (8-OHdG) 的使用.叉头盒-O1 (FOXO1) 是一个氧化压力是一种氧化压力.

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