相关实验视频

Updated: Jun 28, 2025

Establishment and Characterization of Patient-Derived Xenograft Models of Anaplastic Thyroid Carcinoma and Head and Neck Squamous Cell Carcinoma

Establishment and Characterization of Patient-Derived Xenograft Models of Anaplastic Thyroid Carcinoma and Head and Neck Squamous Cell Carcinoma

Published on: June 2, 2023

预后营养指数在预测整体存活率和评估免疫疗法响应时的有效性在形甲状腺癌中

Yongchao Yu^1,2, Kang Ning^1,2, Xinyu Liu³

¹State Key Laboratory of Oncology in South China, Guangdong Provincial Clinical Research Center for Cancer, Sun Yat-sen University Cancer Center, Guangzhou, 510060, China.

|April 24, 2024

概括

预后营养指数 (PNI) 是对形甲状腺癌 (ATC) 存活的重要预测指标. 较高的PNI水平与更好的结果相关,可以帮助评估ATC患者的免疫疗法的有效性.

科学领域:

在瘤学瘤学.
免疫学免疫学免疫学
医学诊断医学诊断医学诊断

背景情况:

形甲状腺癌 (ATC) 中营养状况的预后价值尚未得到充分确立.
预后营养指数 (PNI) 反映了营养和免疫状态,显示了各种癌症的预后意义.
本研究研究了PNI在空中交通中的作用.

研究的目的:

为了评估预后营养指数 (PNI) 的预后价值在形甲状腺癌 (ATC) 中.
评估PNI在预测ATC患者的整体存活率和免疫治疗反应方面的有用性.

主要方法:

对77名ATC患者 (2000-2023) 的系统审查,分为高和低PNI组.
卡普兰-梅尔分析,考克斯回归和ROC曲线分析,以评估PNI对生存和预测价值的影响.
使用Mimics软件进行3D瘤体积重建,以评估治疗反应.

主要成果:

较低的基线PNI与ATC患者的整体存活时间较短显著相关.
PNI显示出对生存的强有力的预测值,AUC值在0.77到0.82.8之间.
PNI和瘤大小是独立的预后因素;免疫治疗后PNI增加与瘤体积减少相关.

结论:

PNI是ATC整体生存的独立预测指标.
PNI显示出作为一个有价值的生物标志物来评估和预测ATC的免疫疗法疗效的潜力.

关键词:

无塑性甲状腺癌是一种甲状腺癌.免疫疗法的反应反应.营养营养营养营养营养预测营养指数的预测.

更多相关视频

Spontaneous Murine Model of Anaplastic Thyroid Cancer

Spontaneous Murine Model of Anaplastic Thyroid Cancer

Published on: February 3, 2023

An Orthotopic Mouse Model of Anaplastic Thyroid Carcinoma

An Orthotopic Mouse Model of Anaplastic Thyroid Carcinoma

Published on: April 17, 2013

相关概念视频

Cancer Survival Analysis

Cancer Survival Analysis

Cancer survival analysis focuses on quantifying and interpreting the time from a key starting point, such as diagnosis or the initiation of treatment, to a specific endpoint, such as remission or death. This analysis provides critical insights into treatment effectiveness and factors that influence patient outcomes, helping to shape clinical decisions and guide prognostic evaluations. A cornerstone of oncology research, survival analysis tackles the challenges of skewed, non-normally...

Tumor Immunotherapy

Tumor Immunotherapy

Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.

Inflammatory Bowel Disease III: Diagnostic Studies and Management I-Nutritional Therapy

Inflammatory Bowel Disease III: Diagnostic Studies and Management I-Nutritional Therapy

Various diagnostic tests are employed in the diagnostic process for Inflammatory Bowel Disease (IBD), particularly to differentiate between Crohn's disease and ulcerative colitis.
Diagnostic studies
A colonoscopy is the definitive screening test, distinguishing ulcerative colitis from other colon diseases with similar symptoms. During a colonoscopy test, inflamed mucosa with exudate ulcerations can be observed, and biopsies are taken to determine the histologic characteristics of the...