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预测严重肥胖的青少年的休息能量消耗:一个多中心分析
Amy A Rydin1, Cameron Severn2,3, Laura Pyle2,3
1Section of Pediatric Endocrinology, Department of Pediatrics, Children's Hospital Colorado, University of Colorado Anschutz Medical Campus, Aurora, Colorado, USA.
Pediatric obesity
|April 24, 2024
概括
为严重肥胖的青少年开发了一种新的休息能量消耗 (REE) 方程. 该方程与现有公式相比,提高了预测准确度,有助于为患有肥胖相关并发症的年轻人做出临床决策.
科学领域:
- 儿科内分泌学 儿科内分泌学
- 代谢医学是一种代谢医学.
- 肥胖问题研究研究
背景情况:
- 休息能量消耗 (REE) 对于管理体重指数 (BMI) 较高的青少年至关重要.
- 现有的REE预测方程对于严重肥胖和相关健康问题的人来说通常是不准确的.
- 准确的REE评估对于有效的临床治疗计划在这个人群中至关重要.
研究的目的:
- 在严重肥胖的青少年中开发和验证REE的新型预测方程.
- 将新方程式的性能与现有的REE预测公式进行比较.
- 为儿童肥胖管理提供更准确的临床决策工具.
主要方法:
- 来自间接热量计,临床测量和DXA身体成分的数据从五个临床地点收集.
- 在发展队列 (N=438) 上使用弹性净回归开发了一个预测方程,并在单独的队列 (N=118) 上进行了验证.
- 关键预测因素包括性别,种族,种族,体重,身高,BMI百分位数,腰部/部周长,年龄,Tanner阶段和身体组成.
主要成果:
- 最终的队列包括556名青少年 (平均年龄15岁,77%为女性) 患有严重肥胖 (BMIp95 = 3.3).
- 开发的方程 (REE = -2048 + 18.17*身高 - 2.57*体重 + 7.88*BMIp95 + 189*性别) 显示出很好的匹配 (R2=0.466) 与最小偏差 (23卡路里/天).
- 与此前发表的11个REE预测方程相比,新方程的准确性得到了改进.
结论:
- 为患有严重肥胖的青少年提出了一种新的,经过验证的REE预测方程.
- 这个方程通过结合与当代儿科肥胖及其并发症相关的因素来提高准确性.
- 这些发现支持使用这个更新的方程,为严重肥胖的年轻人提供临床管理策略的信息.
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