重叠的Streptococcus pyogenes和Streptococcus dysgalactiae亚种等同于家庭传播和移动遗传元素交换
Ouli Xie1,2, Cameron Zachreson3, Gerry Tonkin-Hill4
1Department of Infectious Diseases, University of Melbourne at the Peter Doherty Institute for Infection and Immunity, Melbourne, VIC, Australia.
Nature communications
|April 24, 2024
概括
在澳大利亚的社区中,Streptococcus dysgalactiae亚种equisimilis (SDSE) 和Streptococcus pyogenes一起流传. 基因组分析揭示了这些相关细菌之间广泛的水平基因转移 (HGT) 和共享的移动遗传元素.
科学领域:
- 微生物学 微生物学
- 基因组学就是基因组学.
- 流行病学 流行病学
背景情况:
- Streptococcus dysgalactiae亚种equisimilis (SDSE) 和Streptococcus pyogenes是密切相关的细菌,它们共享生态.
- 这两种病原体都与严重的疾病负担有关,特别是在脆弱人群中.
- 以前的研究表明,这些物种之间存在基因组同样性和水平基因转移 (HGT),但跨物种传播动态尚不清楚.
研究的目的:
- 调查SDSE和S. pyogenes之间跨物种传播和HGT的模式.
- 分析来自澳大利亚偏远第一民族社区的纵向家庭调查的基因组数据.
- 了解疾病控制在高负担环境中的影响.
主要方法:
- 从4547个人的咨询中对294个SDSE和315个S. pyogenes分离物的基因组分析.
- 从偏远的澳大利亚第一民族社区获得的纵向家庭调查数据.
- 携带特定基因的移动遗传元素 (MGE) 的识别和表征.
主要成果:
- 在家庭中观察到SDSE和S. pyogenes传播的广泛交叉.
- 传播模式表明独立传播,没有显著的物种间干扰.
- 在19%的SDSE和7%的S. pyogenes分离物中发现了携带抗微生物耐药性或毒性基因的几乎相同的跨物种MGE.
- 在高负担链球菌病情环境中,证明了病原体和HGT的同时循环.
结论:
- 在澳大利亚偏远社区,SDSE和S. pyogenes通过HGT共同传播和相互作用.
- 共享的MGEs的存在凸显了耐药性和毒性特征快速传播的潜力.
- 对SDSE和S. pyogenes的综合监测和控制策略是有必要的.
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