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在新的CD4+ T细胞表位的鉴定中+

Paul M Zdinak1,2,3, Nishtha Trivedi1,2, Stephanie Grebinoski1,3

  • 1Department of Immunology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.

Nature methods
|April 24, 2024
PubMed
概括

研究人员开发了MHC-II (SABR-II) 的信号和抗原呈现双功能受体,以识别CD4+T细胞抗原. 这个平台可以快速发现T细胞的特异性,这对于了解1型糖尿病等疾病至关重要.

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T Cell Activation and Clonal Selection01:22

T Cell Activation and Clonal Selection

T cells are integral to our adaptive immune system, recognizing and effectively responding to foreign antigens. T cell activation and clonal selection are pivotal in orchestrating this immune response. This article elucidates these mechanisms, detailing the roles of cluster of differentiation (CD) markers, major histocompatibility complex (MHC) molecules, costimulatory signals, and the process of clonal selection.
Naive T cells that have not yet encountered an antigen express two primary CD...
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