人类母乳衍生的强化剂与葡萄糖,和失调有关
Danielle Ackley1, Jiamin Yin2, Carl D'Angio3
1Division of Neonatology, University of Rochester School of Medicine and Dentistry, Rochester, NY, USA. danielle_ackley@urmc.rochester.edu.
概括
在新生儿重症监护室 (NICU) 转换为母乳衍生强化剂 (HM-fort) 与早产婴儿的低血糖,高血和高血糖率较高有关. 这些发现表明,与HM-fort和捐赠人乳 (DHM) 相关的潜在代谢障碍.
科学领域:
- 新生儿科学 新生儿科学
- 儿童营养学 儿童营养学
- 临床化学 临床化学
背景情况:
- 新生儿重症监护室 (NICU) 经常使用强化剂来满足早产婴儿的营养需求.
- 2017年发生了一种转变,即在怀孕30周或之前出生或体重≤1250克的婴儿从牛乳 (BOV-fort) 转向人乳 (HM-fort) 和捐赠人乳 (DHM) 的增强剂.
- 事观察表明,过渡后代谢异常的增加.
研究的目的:
- 为了研究早产婴儿与牛奶来源的强化剂之间的实验室差异,而不是人乳来源的强化剂.
- 评估HM-fort/DHM与特定的代谢障碍 (如低血糖症,高血症和高血症) 之间的关联.
主要方法:
- 一项回顾性分析比较了402名早产儿的实验室测量结果.
- 婴儿被分类,根据接受牛乳来源的强化剂 (BOV-fort,n=232) 或母乳来源的强化剂 (HM-fort,n=170).
- 从2015年至2019年之间出生的婴儿收集数据.
主要成果:
- 在接受HM-fort的婴儿中,血糖水平≤45 mg/dL (p<0.0001) 的比例显著更高.
- 在HM-fort组的婴儿中,更大比例的婴儿经历了高于8.0 mg/dL (p<0.0001) 的水平.
- 在HM-fort组中,婴儿的含量>11.4 mg/dL (p=0.019) 的比例也更高.
结论:
- 在极度早产婴儿中使用母乳衍生强化剂和捐赠母乳与代谢障碍有关.
- 这些发现突显出需要仔细监测接受HM-fort和DHM的婴儿的葡萄糖,和水平.
- 可能需要进一步的研究来了解这些代谢变化背后的机制.
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