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Updated: Jun 28, 2025

Proliferation and Differentiation of Murine Myeloid Precursor 32D/G-CSF-R Cells
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通过破坏IL-2信号和线粒体功能来抑制TIL扩张

Matteo Morotti1,2,3, Alizee J Grimm1,2,3, Helen Carrasco Hope1,2

  • 1Ludwig Institute for Cancer Research, Lausanne Branch, University of Lausanne (UNIL), Lausanne, Switzerland.

Nature
|April 24, 2024
PubMed
概括

通过阻断IL-2信号传递,使瘤微环境中的T细胞功能受损. 抑制PGE2可以增强T细胞扩张和抗瘤反应,从而提高采用细胞治疗的疗效.

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