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在没有抗原刺激的情况下,CARs的细胞外域会重新编程T细胞代谢

Aliya Lakhani1, Ximin Chen1, Laurence C Chen1

  • 1Department of Chemical and Biomolecular Engineering, University of California, Los Angeles, Los Angeles, CA, USA.

Nature metabolism
|April 24, 2024
PubMed
概括

化学抗原受体 (CAR) -T细胞代谢由CARs重编程,影响T细胞功能. 特定的CAR设计增强营养吸收和糖解,这对于有效的CAR-T细胞治疗至关重要.

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