腹膜透析相关腹膜炎的致病谱和风险因素:单中心回顾性研究
Linshuang You1, Baoguo Zhang1, Fan Zhang1
1Department of Nephropathy, The Central Hospital of Yongzhou, Yongzhou, China.
BMC infectious diseases
|April 24, 2024
概括
腹膜透析相关腹膜炎 (PDAP) 影响超过一半的患者,饮食,教育和环境等因素起着关键作用. 可吸收的PDAP病例通常涉及真菌或多种细菌,导致治疗停止.
科学领域:
- 腎臟病學 (nephrology) 是一種醫學專業.
- 传染性疾病 传染性疾病
- 流行病学 流行病学
背景情况:
- 腹腔透析 (PD) 是末期病的重要治疗方法.
- 腹膜炎仍然是一个显著的并发症,影响PD患者的结果.
- 了解PD相关腹膜炎 (PDAP) 风险因素对于预防和管理至关重要.
研究的目的:
- 在中国永州调查PDAP的病原性谱.
- 确定与PDAP发展和难以治愈的病例相关的风险因素.
- 分析微生物耐药性模式,以有效选择抗生素.
主要方法:
- 来自PD患者 (2016-2020) 的临床和流行病学数据的回顾性分析.
- 对炎相关因素的单一因素分析.
- 对于难以处理的PDAP风险因素的多变量逻辑回归.
主要成果:
- 腹膜炎发生在51.9%的PD患者中.
- 关键的危险因素包括低白蛋白,低血红蛋白,低教育,不良饮食和不利的环境条件.
- 格拉姆阳性细菌,特别是葡萄球菌表皮菌,是最常见的;像大肠杆菌这样的格拉姆阴性细菌也被确定. 真菌和多种细菌感染与死亡率有关.
结论:
- 生活方式,教育程度和环境因素对PDAP有很大影响.
- 有效的管理需要解决这些可修改的风险因素.
- 及时识别和有针对性的抗生素治疗是必不可少的,特别是在难以治疗的病例.
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