在结核病患者的肠道细菌和真菌失生症
MeiQing Han1,2, Xia Wang1, JiaMin Zhang1
1Department Four of Tuberculosis Medicine, The First Affiliated Hospital, Xinxiang Medical University, Xinxiang, China.
BMC microbiology
|April 24, 2024
概括
结核病 (TB) 患者表现出肠道细菌和真菌的改变,影响微生物平衡. 特定的肠道微生物可以作为辅助结核病诊断的潜在生物标志物.
科学领域:
- 微生物学 微生物学
- 免疫学 免疫学 免疫学
- 医学诊断 医学诊断 医学诊断
背景情况:
- 越来越关注结核病 (TB) 患者的肠道微生物变化.
- 关于结核病中的肠道真菌 (菌群) 修饰的有限研究.
- 需要了解肠道细菌-真菌相互作用及其与宿主免疫的联系.
研究的目的:
- 在结核病患者中表征肠道细菌和真菌失生症.
- 评估肠道微生物组组成和血清细胞因子之间的相关性.
- 确定结核病的潜在诊断生物标志物.
主要方法:
- 在结核病患者和对照组中对肠道微生物群 (细菌和真菌) 的比较分析.
- 评估α多样性和微生物组成.
- 与血清细胞因子 (IL-17,IFN-γ) 的相关性分析.
主要成果:
- 结核病患者的肠道微生物群多样性减少和组成变化.
- 增加了细菌菌和prevotella;减少了蓝斑和双菌.
- 增加了Saccharomyces和减少了Aspergillus真菌.
- 减少了真菌与细菌的比率和跨王国的相互作用.
- 一个微生物模型 (Bacteroides, Blautia, Eubacterium_hallii_group, Apiotrichum, Penicillium, Saccharomyces) 显示出诊断的潜力.
- 肠道功能障碍与改变的IL-17和IFN-γ水平有很强的相关性.
结论:
- 结核病患者表现出显著的肠道细菌和真菌失生症.
- 肠道微生物形状为结核病诊断提供了潜在的辅助生物标志物.
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