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H₂S驱动的化疗和温和的光热疗法诱导了线粒体重编程以促进cuproptosis

Lihong Qiao^1,2,3,4, Yijing Ou^1,2, Lin Li^1,2

¹Department of Obstetrics and Gynecology, The Tenth Affiliated Hospital of Southern Medical University (Dongguan People's Hospital), Dongguan, Guangdong, 523058, People's Republic of China.

Journal of nanobiotechnology

|April 24, 2024

概括

这项研究引入了新的纳米粒子 (TCuH),通过利用高硫化 (H2S) 水平来向结肠癌. 这种TCuH纳米颗粒结合了H2S驱动的cuproptosis,化疗和光热疗法,以增强抗瘤效果.

科学领域:

生物医学工程生物医学工程
纳米技术纳米技术
在瘤学瘤学.

背景情况:

结肠癌中硫化 (H2S) 水平升高是一个治疗挑战,也是治疗目标.
由于H2S,传统的单一疗法不足以完全治愈结肠癌.
开发多功能纳米平台对于协同抗瘤战略至关重要.

研究的目的:

开发基于H2S响应纳米颗粒的多功能级联生物反应器,用于协同结肠癌治疗.
为了研究H2S驱动的cuproptosis,化疗和光热疗法的综合作用.
评估氨酸涂层纳米颗粒的准和治疗疗效.

主要方法:

制造TPZ@Cu2Cl(OH) 3-HA (TCuH) 纳米颗粒,封装着提拉巴胺 (TPZ),装有Cu2Cl(OH) 3,涂上氨酸 (HA).
在近红外II (NIRII) 辐射下利用H2S反应能力在现场生成硫化铜 (Cu9S8) 和TPZ释放.
研究过缺氧诱导,线粒体重编程和铜离子 (Cu2+) 介导的和化学动力学治疗.

主要成果:

TCuH纳米颗粒通过结合H2S驱动的cuproptosis,TPZ化疗和温和的光热疗法,证明了协同作用的抗瘤作用.
HA涂层促进了向的输送,并增强了瘤组织中的药物积累.
该系统有效诱导了cuproptosis,化疗和化学动力学疗法,导致显著的瘤抑制.

结论:

TCuH纳米颗粒代表了在结肠癌中协同抗瘤治疗的多功能平台.
疗法组合有效地准瘤微环境,克服单一治疗方法的局限性.
这种方法对开发利用特定瘤生物标志物的先进癌症治疗策略具有前景.

关键词:

化学动力学疗法是一种化学动力学疗法.这种疾病叫做cuproptosis.对H2S有反应性的轻度的光热疗法是一种轻度的光热疗法.线粒体重编程的重编程

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