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抗糖尿病药物使用的趋势和区域差异:全国性的回顾性观察性研究
Márta Csatordai1,2, Ria Benkő1,2, Mária Matuz1,2
1Faculty of Pharmacy, Institute of Clinical Pharmacy, University of Szeged, Szikra utca 8, 6725, Szeged, Hungary.
Diabetology & metabolic syndrome
|April 24, 2024
概括
在匈牙利,抗糖尿病药物的使用量增加,新型药物如DPP4Is,GLP1As和SGLT2Is的使用量增加. 药物消费仍然存在显著的区域差异,特别是在硫氨基酸和较新的药物中.
科学领域:
- 药理学 药理学是指药理学的学科.
- 公共卫生 公共卫生
- 内分泌学 在内分泌学.
背景情况:
- 全球糖尿病患病率上升需要更新治疗策略.
- 较新的抗糖尿病药物类别在与既定疗法相辅相成,提供了更好的疗效.
- 了解药物使用模式对于优化糖尿病护理至关重要.
研究的目的:
- 分析2015-2021年匈牙利抗糖尿病药物消费趋势.
- 调查匈牙利各县使用毒品的区域差异.
- 确定影响这些区域差异的潜在社会经济决定因素.
主要方法:
- 全国批发药物数据库 (2015-2021) 的回顾性分析.
- 通过每天1000名居民的定义每日剂量 (DDD/TID) 来量化药物使用.
- 使用最大/最小比率和与失业率和公共医疗卡持有者等决定因素的相关性来评估区域差异.
主要成果:
- 总体而言,抗糖尿病药物的使用量增长了7.6%,在2021年达到94.8 DDD/TID.
- 甲胺和新药 (DPP4Is,GLP1As,SGLT2Is) 的利用率有所增加,而硫基尿素的利用率有所下降.
- 观察到显著的区域差异,特别是GLP1As (最大/最小比:3.00) 和SGLT2Is (1.92).
- 失业率与硫氨酸尿素使用相关;公共医疗卡持有者与人胰岛素和硫氨酸尿素使用相关.
结论:
- 新型抗糖尿病药物使用的动态增长与匈牙利持续大量的硫基尿素消费形成鲜明对比.
- 抗糖尿病药物消费的区域差异显著,突显了未得到满足的需求或不同的处方做法.
- 进一步研究影响区域处方模式的社会经济因素是有必要的.
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