了解矩阵:瘤中的原修饰及其对免疫治疗的影响
Rowie Borst1,2, Linde Meyaard1,2, M Ines Pascoal Ramos3,4,5
1Center for Translational Immunology, University Medical Center Utrecht, Utrecht University, Utrecht, The Netherlands.
Journal of translational medicine
|April 24, 2024
概括
瘤细胞外基质 (ECM),特别是原,显著影响癌症生长和免疫反应. 向原及其修饰为癌症治疗提供了有前途的治疗策略.
科学领域:
- 在瘤学瘤学.
- 癌症生物学 癌症生物学
- 免疫治疗是一种免疫疗法.
背景情况:
- 瘤是复杂的生态系统,涉及恶性细胞,健康细胞和细胞外基质 (ECM).
- 构成高达60%瘤质量的ECM支持癌细胞生存,生长,并影响对免疫治疗的反应.
- 原蛋白是最丰富的ECM蛋白家族,已知28个亚型经历了翻译后修饰 (PTM).
研究的目的:
- 审查有关瘤原蛋白组成和原蛋白PTMs影响的当前知识.
- 探索原蛋白变化如何影响癌症进展和免疫反应.
- 讨论针对新型癌症治疗的原和细胞-ECM相互作用的潜力.
主要方法:
- 对瘤原蛋白当前研究的文献综述.
- 对原体翻译后修饰 (PTMs) 的后果的分析.
- 讨论对瘤免疫和治疗策略的影响.
主要成果:
- 瘤原蛋白组成和PTM显著改变受体结合,细胞迁移和瘤度.
- 这些原蛋白修饰极大地影响瘤微环境和免疫细胞相互作用.
- 向原及其相互作用是增强免疫治疗和开发新癌症治疗的可行策略.
结论:
- 原及其PTM是瘤进展和免疫逃避的关键调节者.
- 向瘤ECM,特别是原,具有显著的治疗潜力.
- 对原导向疗法的进一步研究可能会彻底改变癌症治疗和免疫疗法.
相关概念视频
02:17The Tumor Microenvironment
6.6K
Every normal cell or tissue is embedded in a complex local environment called stroma, consisting of different cell types, a basal membrane, and blood vessels. As normal cells mutate and develop into cancer cells, their local environment also changes to allow cancer progression. The tumor microenvironment (TME) consists of a complex cellular matrix of stromal cells and the developing tumor. The cross-talk between cancer cells and surrounding stromal cells is critical to disrupt normal tissue...
6.6K
01:27Tumor Immunotherapy
520
Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.
520