瑞COVID19疫苗与急性心血管事件无关,除了心肌炎 - 一项全国自控病例系列研究
Lital Keinan Boker1,2, Ronen Fluss3, Rita Dichtiar4
1Israel Center for Disease Control, Ministry of Health, Sheba Medical Center, Gertner bldg, 52621, Tel Hashomer, Ramat Gan, Israel. Lital.keinan2@moh.gov.il.
Israel journal of health policy research
|April 24, 2024
概括
瑞COVID-19疫苗的第二剂量并没有增加急性心血管事件或死亡的风险. 这项研究没有发现接种疫苗后风险增加,解决了公众对疫苗安全性的担忧.
科学领域:
- 心脏病学 心脏病学
- 疫苗学 疫苗学 疫苗学
- 公共卫生 公共卫生
背景情况:
- 关于COVID-19疫苗接种后心血管风险和死亡率的公众担忧仍然存在.
- 之前的研究表明没有增加风险,但公众的担忧仍然存在.
- 这项研究专门研究了第二剂瑞-生物科技COVID-19疫苗接种后的短期风险.
研究的目的:
- 为了评估急性心血管事件 (不包括心肌炎) 的风险,在第二剂瑞-生物科技COVID-19疫苗接种后需要住院治疗.
- 为了评估第二剂Pfizer-BioNTech COVID-19疫苗接种后的短期死亡风险.
主要方法:
- 一个自我控制的案例系列 (SCCS) 研究设计利用了以色列的国家数据库.
- 包括2021年1月至10月期间接受第二剂疫苗的个人,而没有先前的COVID-19诊断.
- 在接种疫苗后的30天 (风险期) 与随后的30天 (控制期) 的事件进行了比较,使用条件后勤回归.
主要成果:
- 在570万接种疫苗的人中,4163人经历了急性心血管事件;没有观察到显著的风险增加 (OR=0.95,P=0.12).
- 经过调整后的分析证实没有增加的风险 (aOR=0.88).
- 没有发现特定于年龄的风险增加,死亡率数据也没有显示出任何重大问题.
结论:
- 在第二剂瑞-生物科技COVID-19疫苗接种后,没有发现急性心血管事件 (除心肌炎) 的风险增加.
- 死亡率数据没有表明风险增加,尽管注意到了潜在的偏差.
- 这些发现有助于了解COVID-19疫苗在心血管健康方面的安全概况.
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