食补充剂:临床降胆固醇功效和潜在的作用机制
1Institute of Quality Standard and Testing Technology of Agricultural Products, Ningxia Academy of Agriculture and Forestry Sciences, Yinchuan, China.
International journal of food sciences and nutrition
|April 25, 2024
概括
某些食补充剂可以降低高胆固醇患者的胆固醇和LDL水平. 这些补充剂通过各种机制起作用,包括胆酸分泌和胆固醇吸收抑制.
科学领域:
- 营养科学 营养科学
- 心血管健康 心血管健康
- 药理学 药理学是指药理学的学科.
背景情况:
- 血胆固醇水平升高,特别是低密度脂蛋白 (LDL) 胆固醇,是心血管疾病的重要危险因素.
- 饮食干预越来越多地被探索为管理高胆固醇血症的补充策略.
- 了解食补充剂的疗效和机制对于基于证据的建议至关重要.
研究的目的:
- 系统地审查各种食补充剂在降低血胆固醇水平方面的有效性.
- 分析随机对照试验 (RCT) 的元分析证据.
- 探索这些补充剂降胆固醇作用的潜在作用机制.
主要方法:
- 随机对照临床试验的元分析是证据的主要来源.
- 研究包括人类,动物和基于细胞的研究,以阐明作用机制.
- 专注于证明对血脂质概况有显著影响的补充剂.
主要成果:
- 一些食补充剂,包括植物,柏柏林,粘性可溶纤维,大,大豆蛋白,特定益生菌和多提取物,显著降低了总和LDL胆固醇.
- 降低范围从3-25%,在高胆固醇贫血患者中观察到的效果更大,而不是正常胆固醇水平的人.
- 确定的机制包括增强胆汁酸分泌,抑制胆固醇吸收,增加肝脏LDL受体表达,抑制胆固醇合成酶和AMPK信号的激活.
结论:
- 食补充剂为管理高胆固醇水平,特别是LDL胆固醇提供了可行的选择.
- 功效和机制在补充剂之间有所不同,突出了个性化方法的必要性.
- 对特定的补充-菌体相互作用和长期结果的进一步研究是有必要的.
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