动脉样硬化和高风险结直肠腺瘤之间的关联基于心脚血管指数和脚臂指数
Jung Ho Lee1, Hyunseok Cho2, Sang Hoon Lee1
1Department of Internal Medicine, Kangwon National University College of Medicine, Chuncheon, Korea.
概括
心血管指数 (CAVI) 可以预测高风险结肠直肠腺瘤,这是癌前病变. 这项研究发现,阳性CAVI和高风险腺瘤之间存在显著的相关性,这表明CAVI.
科学领域:
- 胃肠病学 胃肠病学
- 心脏病学 心脏病学
- 预防医学 预防医学
背景情况:
- 结肠直肠腺瘤是与结肠直肠癌相关的癌前病变.
- 新出现的证据表明结直肠腺瘤和动脉样硬化之间存在关联.
- 心血管指数 (CAVI) 和脚腕指数 (ABI) 是动脉样硬化的非侵入性标志物.
研究的目的:
- 调查通过CAVI和ABI评估的动脉样硬化和高风险结直肠腺瘤之间的关系.
- 确定CAVI或ABI是否可以作为高风险结直肠腺瘤的预测因素.
主要方法:
- 追溯分析1,164名年龄≥50岁的患者,这些患者接受了结肠镜检查和CAVI/ABI测量.
- 根据病理发现,将受试者分为没有腺瘤,整体腺瘤和高风险腺瘤组.
- 应用单变量和多变量逻辑回归分析来评估关联.
主要成果:
- 在10.1%的受试者中发现了高风险腺瘤.
- 阳性CAVI (≥9.0) 和阳性ABI (<0.9) 率在高风险腺瘤组明显高于其他组 (p=0.006和p=0.008).
- 多变量分析表明,阳性CAVI (OR 1.595) 和吸烟状态 (OR 1.579) 与高风险腺瘤有显著联系.
结论:
- 阳性CAVI和高风险结直肠腺瘤的存在之间存在显著的相关性.
- 卡维显示潜在的作为一个重要的预测指标,识别患有高风险结直肠腺瘤的患者.
- 这些发现可能有助于对结直肠瘤的风险分层和早期检测策略.
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