通过微透析在患有或没有实验性腹膜炎的老鼠腹膜液中的Cefepime分布
Michele Vaz Dos Anjos1, Eduarda Possa1, Gisele da Silva Fonseca2
1Health Sciences Postgraduate Program, University of Caxias do Sul, Caxias do Sul, Brazil.
概括
这项研究表明,cefepime有效地穿透大鼠腹液,在健康和败血症模型中保持度高于感染值. 感染并没有显著改变cefepime的药理动力学.
科学领域:
- 药理学 药理学是指药理学的学科.
- 传染性疾病 传染性疾病
- 药物运输 药物运输 药物运输
背景情况:
- 塞菲皮姆是治疗严重感染的关键抗生素.
- 了解其透到特定的身体腔内,如腹腔液,对于优化治疗至关重要,特别是在败血症中.
- 之前的研究缺乏有关感染期间腹液中未结合的塞费皮姆度的数据.
研究的目的:
- 使用微透析量化Cefepime透于大鼠腹腔液.
- 为了将未结合的塞费皮姆度与腹膜液度相关联.
- 在败血症诱导的周周炎模型中评估cefepime的药理动力学行为.
主要方法:
- 微透析被用来测量cefepime度在腹膜液和血中的体内.
- 液体染色学-电子喷雾电离-QTOF质谱学 (LC-ESI-QTOF MS) 用于药物定量.
- 在大鼠中,通过结和穿孔 (CLP) 诱导了败血症模型.
主要成果:
- 在对照组和腹膜炎组中,塞费皮姆在腹膜液中迅速分布.
- 周液与血的Cefepime比率大约为0.32-0.38.
- 达到的塞费皮姆度仍然高于关键肠道细菌的最小抑制度 (MIC).
结论:
- 在老鼠中,Cefepime表现出良好的透到腹膜液中.
- 实验性腹膜炎模型没有显著影响cefepime的药理动力学.
- 这项研究提供了关于在健康和实验性腹膜炎期间腹膜液中自由塞费皮姆度的第一个数据.
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