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在接受放射治疗的鼻癌患者中,营养状况可以在一周前预测疲劳吗?
Jihong Song1,2, Xinru Yang2, Jieling Wu2
1School of Nursing, Health Science Center, Xi'an Jiaotong University, Xi'an, China.
Cancer medicine
|April 25, 2024
概括
鼻癌患者在辐射治疗的第五周左右会出现峰值疲劳. 通过PG-SGA评估的营养状况比身体组成更好地预测未来的疲劳,特别是当考虑焦虑和抑郁时.
科学领域:
- 在瘤学瘤学.
- 辐射疗法 辐射疗法
- 患者报告的结果
背景情况:
- 鼻癌 (NPC) 的放射治疗会引起显著的,往往被低估的患者疲劳.
- 缺乏评估NPC患者疲劳的客观指标.
- 这项研究调查了疲劳和营养状况在一周前之间的预测关系.
研究的目的:
- 在接受放射治疗的NPC患者中探索疲劳和营养状况之间的纵向关联.
- 为了确定NPC治疗期间未来疲劳的可靠预测因素.
- 评估身体组成和心理因素对疲劳的影响.
主要方法:
- 一项纵向观察性研究包括105名接受强度调节放射治疗的NPC患者.
- 每周的评估 (T0-T7) 包括Piper Fatigue Scale-12 (PFS-12),得分患者生成的主观全球评估 (PG-SGA),身体组成和医院焦虑和抑郁量表 (HADS).
- 边际结构模型 (MSM) 用于分析这些关系,控制时间依赖的混因素.
主要成果:
- 疲劳 (PFS-12) 在第五周达到顶峰,感官疲劳始终最高,行为疲劳增长最快.
- 较高的PG-SGA得分预测疲劳增加的可能性较低 (β=0.020.04).
- MSM显示了PG-SGA和疲劳之间的更强的关联 (β=0.120.21) 和身体组成和疲劳之间的弱负关系,提前一周.
结论:
- 与个人身体组成指标相比,PG-SGA是下周疲劳的更准确的预测指标.
- 作为一个依赖时间的混因子,控制HADS可以提高PG-SGA对疲劳的预测准确性.
- 这些发现强调了营养评估在治疗NPC患者放射治疗引起的疲劳方面的重要性.
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