在不可切除的肝细胞癌的转化疗法中,基于伦瓦替尼的治疗方案:系统性审查和元分析
Saixin Li1,2, Zeyu Zhang3, Zheng Wang1,2
1Department of General Surgery, Xuanwu Hospital, Capital Medical University, Beijing 100053, P.R. China.
Oncology letters
|April 25, 2024
概括
基于伦瓦替尼的疗法对不可切除的肝细胞癌 (uHCC) 转化有前途. 像伦瓦提尼布加免疫检查点抑制剂 (ICI) 等组合,带或不带区域治疗 (LRT),提供有效的治疗,可接受的安全性.
科学领域:
- 肝胆道恶性瘤 肝胆道恶性瘤
- 在瘤学瘤学.
- 翻译医学是一种翻译医学.
背景情况:
- 肝细胞癌 (HCC) 由于高发病率和死亡率,给全球健康带来了重大挑战.
- 转化疗法为无法切除的HCC (uHCC) 患者提供了彻底治疗和改善生存的途径.
- 对HHCC的最佳转化疗法策略仍然是一个活跃的研究领域.
研究的目的:
- 系统评估基于lenvatinib (LEN) 的治疗方案在hhcc转换疗法的安全性和有效性.
- 为了比较不同的LEN组合策略,包括免疫检查点抑制剂 (ICI) 和局域治疗 (LRT).
主要方法:
- 一项对16项涉及1650名HuhCC患者的研究的元分析.
- 在主要数据库 (MEDLINE,Embase,Web of Science,Cochrane Library) 进行系统的文献搜索,截至2023年9月1日.
- 对结果的分析,包括转化率,客观反应率 (ORR),疾病控制率 (DCR) 和不良事件 (AE) 发生率.
主要成果:
- 汇集的转换率有所不同:单独LEN (0.04),LEN + LRT (0.14),LEN + ICI (0.23),以及LEN + ICI + LRT (0.35).
- 聚合的客观响应率 (ORR) 是LEN + ICI + LRT (0.69) 和LEN + ICI (0.49) 的最高.
- 疾病控制率 (DCR) 在所有组合中普遍较高,其中LEN + ICI + LRT显示最高 (0.87). 观察到≥3级的副作用,其中LEN + ICI (0.43) 和LEN + LRT (0.42) 的发生率更高.
结论:
- 基于伦瓦提尼布的组合策略表明,对HHCC转化疗法具有有效性和可接受的耐受性.
- 伦瓦提尼布加上免疫检查点抑制剂 (ICI),有或没有局部区域疗法 (LRT),代表了一种高度有效的转化疗法.
- 这些组合为患有HHCC的患者提供了一种有前途的方法,具有良好的安全特征.
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