肝病:复杂疾病的流行病学,表现,分类和管理
Rodrigo V Motta1, Francesca Saffioti2,3, Vasileios K Mavroeidis4,5,6
1Translational Gastroenterology and Liver Unit, Nuffield Department of Medicine, University of Oxford, Oxford OX3 9DU, United Kingdom.
World journal of gastroenterology
|April 25, 2024
概括
肝病,或肝内胆道结石,是越来越全球性的. 它涉及反复感染,并可能导致胆道癌症,需要多学科的管理.
科学领域:
- 胃肠病学和肝胆道疾病
- 手术瘤学手术瘤学
- 传染性疾病 传染性疾病
背景情况:
- 肝病的特征是肝内胆道结石,由于社会经济,饮食和寄生因素,在亚洲更为常见.
- 由于迁移,全球发病率正在上升,其中的关键机制包括胆管炎,胆管感染和狭窄,往往导致反复发病胆管炎.
- 慢性肝炎是肝脏内胆管癌的重要危险因素.
研究的目的:
- 为提供关于肝病的综合性综述.
- 专注于流行病学,病理生理学,临床方面,分类和当代管理.
- 突出管理症状患者和并发症所需的复杂性和多学科方法.
主要方法:
- 综合性文献综述,重点关注流行病学,病理生理学,临床表现,分类和肝病的管理.
- 分析当前关于感染和狭窄的自我维持周期的证据.
- 检查肝病和肝脏内胆管癌的发展之间的联系.
主要成果:
- 肝病涉及感染,炎症和胆管内结石形成的复杂相互作用.
- 这种情况与复发性焦热性胆管炎有关,是已知的肝内胆管癌的前体.
- 有效的管理需要多学科的团队方法来缓解症状和预防并发症.
结论:
- 肝病带来了重大的临床挑战,包括复发性感染和癌症风险.
- 对其流行病学和病理生理学的彻底理解对于有效的诊断和治疗至关重要.
- 多学科合作对于优化肝病管理中的患者结果至关重要.
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