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Updated: Jun 28, 2025

Visualization of Mitochondrial Respiratory Function using Cytochrome C Oxidase / Succinate Dehydrogenase COX/SDH Double-labeling Histochemistry
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细胞核核核糖蛋白哈普洛因不足会影响线粒体形态和呼吸

Agustian Surya1, Blythe Marie Bolton1, Reed Rothe1

  • 1Department of Molecular Biosciences, University of Texas at Austin, Austin, TX 78712, USA.

bioRxiv : the preprint server for biology
|April 25, 2024
PubMed
概括

核糖体蛋白质基因损失会损害线粒体功能和能量生产. 细胞适应了氧化应激抵抗的增加,这表明在遗传应激下维持细胞健康的机制得到了保护.

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Translation is the process of synthesizing proteins from the genetic information carried by messenger RNA (mRNA). Following transcription, it constitutes the final step in the expression of genes. This process is carried out by ribosomes, complexes of protein and specialized RNA molecules. Ribosomes, transfer RNA (tRNA), and other proteins produce a chain of amino acids—the polypeptide—as the end product of translation.
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The inner mitochondrial membrane is the primary site of ATP synthesis. The inner membrane domain that forms a smooth layer adjacent to the outer membrane is called the inner boundary membrane. This domain contains membrane transporters that drive metabolites in and out of the mitochondria.  In contrast, the inner membrane network that invaginates into the matrix space is called the cristae membrane. This domain accounts for principle mitochondrial function as it accommodates the protein...
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