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Updated: Jun 28, 2025

Engineering Oncogenic Heterozygous Gain-of-Function Mutations in Human Hematopoietic Stem and Progenitor Cells
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Engineering Oncogenic Heterozygous Gain-of-Function Mutations in Human Hematopoietic Stem and Progenitor Cells

Published on: March 10, 2023

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通过基因间转换来修复白血病相关的单核酸变体

Alexander James Silver, Donovan J Brown, Sarah D Olmstead

    bioRxiv : the preprint server for biology
    |April 25, 2024
    PubMed
    概括

    研究人员开发了一种新的CRISPR-Cas9基因编辑方法,在不需要外部DNA的情况下修复白血病细胞中的单核酸变体 (SNV). 这种基因间转换 (IGC) 方法在异种移植模型中成功地逆转了突变并延长了生存期.

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