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Updated: Jun 28, 2025

Conformational Evaluation of HIV-1 Trimeric Envelope Glycoproteins Using a Cell-based ELISA Assay
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在两种HIV-1 Env免疫方案中,B细胞免疫聚焦和抑制

Jenna M DeLuca1, Maria Blasi2,3, Shalini Jha2,4

  • 1Translational Immunobiology Unit, Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA.

Research square
|April 25, 2024
PubMed
概括

不同的病毒挑战了疫苗设计. 这项研究表明,不同的HIV-1 Env免疫策略引发了不同的记忆B细胞反应,其中一种策略抑制了由于免疫原格式变化而导致的B细胞反应.

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B Cell Activation and Differentiation

The adaptive immune response, a sophisticated defense mechanism, relies on the activation and differentiation of B lymphocytes, or B cells. These processes enable our bodies to mount a tailored response against specific pathogens such as bacteria, free virus particles, toxins, and parasites.
When naive B cells encounter a specific antigen that can bind to the B cell receptor (BCR) on their surface, they undergo sensitization to respond to the antigen's presence. Sensitization begins with...
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