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Updated: Jul 18, 2026

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在GD2导向的化学抗原受体修饰免疫效应细胞治疗神经母细胞瘤后的18年生存率

Li Che-Hsing1,2,3, Sandhya Sharma1, Andras A Heczey1,2,4

  • 1Center for Cell and Gene Therapy, Baylor College of Medicine, Texas Children's Hospital and Houston Methodist Hospital, Houston TX.

Research square
|April 25, 2024
PubMed
概括

长期结果表明,GD2 CAR-T细胞疗法可以导致复发性或耐药性神经母细胞瘤的儿童持续缓解,一些患者超过18年没有疾病.

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Cancer is the second leading cause of death in the United States. A cancer cell is genetically unstable and hence can mutate faster. They can also modify their microenvironment and escape immune surveillance. The difficulties in treating cancer are further compounded by the emergence of rapid resistance to anticancer drugs. The most common ways to attain resistance in cancer cells include alteration in drug transport and metabolism, modification of drug target, elevated DNA damage response, or...
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Treatment Resistent Cancers

Cancer is the second leading cause of death in the United States. A cancer cell is genetically unstable and hence can mutate faster. They can also modify their microenvironment and escape immune surveillance. The difficulties in treating cancer are further compounded by the emergence of rapid resistance to anticancer drugs. The most common ways to attain resistance in cancer cells include alteration in drug transport and metabolism, modification of drug target, elevated DNA damage response, or...