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Updated: Jun 30, 2026

Protein WISDOM: A Workbench for In silico De novo Design of BioMolecules
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对于TLR3的蛋白质迷你结合剂激活剂的新设计

Chloe S Adams1,2, Hyojin Kim3, Abigail E Burtner1,2

  • 1Institute for Protein Design, University of Washington, Seattle, WA, 98195 USA.

bioRxiv : the preprint server for biology
|April 25, 2024
PubMed
概括

研究人员设计了新的小蛋白质,与高亲和力结合到Toll-like受体3 (TLR3). 这些基于蛋白质的激动剂激活免疫信号,为当前基于核酸的TLR3激活剂提供了稳定的替代方案.

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相关概念视频

The Two-State Receptor Model01:29

The Two-State Receptor Model

The two-state receptor model explains a drug's interaction with receptors, such as G protein-coupled receptors and ligand-gated ion channels, to induce or inhibit a biological response. When no natural ligands are present, a receptor exists in an equilibrium of inactive (Ri) and active (Ra) conformations. The inactive form does not produce a response, while the active form generates a basal effect known as constitutive activity.
The binding affinity of a drug determines its interaction with one...