抑郁症与发生心血管疾病之间的关系中的性别差异
Keitaro Senoo1,2, Hidehiro Kaneko3,4, Kensuke Ueno3,5
1Department of Cardiac Arrhythmia Research and Innovation, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kyoto, Japan.
JACC. Asia
|April 25, 2024
概括
抑郁症在两性中都显著增加了心血管疾病 (CVD) 风险,但女性经历了更强烈的联系. 解决抑郁症对于特定性别的心血管疾病预防和管理策略至关重要.
科学领域:
- 心脏病学 心脏病学
- 精神病学是一个精神病学.
- 公共卫生 公共卫生
背景情况:
- 抑郁症是心血管疾病 (CVD) 的确定的危险因素.
- 现有研究尚未完全阐明抑郁症与心血管疾病相关的潜在性别差异.
研究的目的:
- 调查抑郁症和随后的心血管疾病事件之间的联系.
- 探索这种关联中的潜在的性别特异性差异.
主要方法:
- 从JMDC索赔数据库 (2005-2022) 中对4,125,720名个人 (18至75岁) 的回顾性分析.
- 排除以前有心血管疾病或功能衰竭的个人,以及缺少的基线数据.
- 平均1288天的随访,以确定发生的心血管疾病事件 (心肌梗塞,胸痛,中风,心力衰竭,心房动).
主要成果:
- 在男性和女性中发现了抑郁症和复合心血管疾病事件之间的显著关联.
- 在多变量调整 (P相互作用<0.001) 后,女性 (HR 1.64) 与男性 (HR 1.39) 相比,这种关联显著更强.
- 个别的心血管疾病事件组件也显示了与女性抑郁症的更强的关联.
结论:
- 抑郁症与两性中随后心血管疾病事件的风险增加有显著的关联.
- 与男性相比,女性在抑郁症和心血管疾病风险之间表现出更明显的关联.
- 研究结果强调,需要在抑郁症管理和心血管疾病预防策略中采取性别特定的方法.
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