一个新的基于Web的动态预后诺莫格拉姆对于胃结环细胞癌:一个多中心基于人口的研究
Yujuan Jiang1, Haitao Hu1, Xinxin Shao1
1Department of Pancreatic and Gastric Surgery, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
Frontiers in immunology
|April 25, 2024
概括
这项研究开发了预后诺基图来预测胃结环细胞癌 (GSRCC) 患者的整体存活率和癌症特异性存活率. 这些经过验证的工具可以通过Web服务器访问,帮助医生估计GSRCC患者的治疗结果.
科学领域:
- 在瘤学瘤学.
- 医学统计 医学统计
背景情况:
- 胃封印环细胞癌 (GSRCC) 是一种罕见的,高度恶性胃癌亚型.
- GSRCC与预后不佳有关,因此需要改进生存预测工具.
研究的目的:
- 开发和验证用于预测GSRCC患者的整体生存率 (OS) 和癌症特异性生存率 (CSS) 的预后性名录.
- 为了确定GSRCC的独立预后因素.
主要方法:
- 使用国家癌症中心和SEER数据库 (2011-2018) 的回顾性队列研究.
- 使用单变量和多变量考克斯回归分析构建的预测名录.
- 通过校准曲线,C指数,ROC和DCA曲线进行模型验证;进行内部和外部验证.
主要成果:
- 纳米图包括六个预测因素:年龄,种族,瘤部位,瘤大小,N期,T期和AJCC期.
- 内部和外部校准图表之间非常好的一致性.
- C指数和ROC曲线下的面积> 0.7,表明良好的预测准确性.
结论:
- 基于Web的动态诺姆图 (nomograms) 已经开发出来,用于估计GSRCC患者的OS和CSS.
- 这些工具使用六个独立的预后变量来帮助临床决策.
- 可访问的Web服务器提供了一个用户友好的平台来应用名ograms.
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