在无症状和症状患者中,血管网症与COVID-19严重程度的关联
Suman Kapoor1, Lucia Mihalovičová2,3, Ekaterina Pisareva2
1Thumbay Research Institute for Precision Medicine, Gulf Medical University, Ajman, UAE.
iScience
|April 25, 2024
概括
中性粒细胞外细胞陷 (NETs) 标记物,如中性粒细胞弹性酶 (NE) 和髓氧化酶 (MPO),随着COVID-19的严重程度显著增加. 意想不到的是,与健康对照组相比,无症状个体的NETs更高.
科学领域:
- 免疫学 免疫学 免疫学
- 病理生理学 病理生理学
- 分子生物学分子生物学
背景情况:
- 中性细胞外细胞陷 (NETs) 与炎症性疾病有关.
- 了解NET在COVID-19严重性中的作用对于患者管理至关重要.
研究的目的:
- 调查NETs标记物与COVID-19疾病严重程度之间的关联.
- 为了比较感染患者,无症状个体和健康对照中的NETs水平.
主要方法:
- 从549名COVID-19患者和140名健康个体的血中分析了中性粒细胞弹性酶 (NE),骨髓氧化酶 (MPO) 和循环核DNA (cir-nDNA).
- 根据疾病严重程度 (轻度,中度,严重,危急) 的患者分层.
- 跨不同群体的NET标志物的比较和与疾病进展的相关性.
主要成果:
- 随着COVID-19严重程度的升级,NE,MPO和cir-nDNA的血水平显著增加 (p < 0.0001).
- 与健康个体相比,在所有COVID-19严重程度组中,NETs标志物显著升高 (p < 0.0001).
- 无症状个体的NETs水平明显高于健康个体 (p < 0.0001).
- 线粒体功能障碍是由COVID-19患者的改变的cir-nDNA和循环线粒体DNA水平表明的.
结论:
- NETs标记是COVID-19严重程度的可靠指标.
- 无症状个体中NETs的升高表明亚临床炎症反应.
- 网和线粒体功能障碍可能在COVID-19病变发生过程中发挥关键作用.
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