间接治疗比较方法:从系统文献综述中得出的结果
Bérengère Macabeo1,2, Arthur Quenéchdu3, Samuel Aballéa1,4
1Department of Public Health, Aix-Marseille University, 13005 Marseille, France.
Journal of market access & health policy
|April 25, 2024
概括
在没有直接试验数据的情况下,间接治疗比较 (ITC) 提供了替代证据. 本综述评估了七种ITC技术,以指导其在卫生技术评估 (HTA) 中的使用.
科学领域:
- 卫生技术评估 卫生技术评估
- 相对有效性研究研究比较
- 证据综合 证据综合
背景情况:
- 卫生技术评估 (HTA) 机构优先考虑随机对照试验来评估治疗有效性.
- 间接治疗比较 (ITC) 在直接比较数据不可或不可能时至关重要.
- 为了分析现有的ITC方法,进行了系统文献审查 (SLR).
研究的目的:
- 识别和描述各种ITC技术.
- 从HTA的角度评估每个技术的优点和局限性.
- 为在不同临床场景中选择适当的ITC方法制定指导方针.
主要方法:
- 使用Embase和PubMed数据库进行了系统文献审查 (SLR),并通过灰色文献搜索进行了补充.
- 包括详细介绍ITC方法的同行评审文章,遵守PRISMA指南.
- 审查的重点是确定和描述七种不同的ITC技术.
主要成果:
- 在73篇文章中确定了7种调整的ITC技术,其中网络元分析 (NMA) 是最常见的.
- 其他技术包括匹配调整间接比较 (MAIC),网络元回归,布切尔方法,模拟治疗比较 (STC),倾向得分匹配和治疗权重的逆概率.
- 选择ITC方法取决于网络连接,异质性,研究量和数据可用性 (例如个人患者级数据).
结论:
- 在没有直接的比较数据的情况下,ITC提供了有价值的证据.
- 目前,HTA机构对ITC的接受度有限,需要更明确的国际共识和方法指导.
- 信息通信领域正在迅速发展,未来有可能出现更高效的技术.
关键词:
一个屠夫,一个屠夫.间接治疗比较 (ITC)经匹配调整的间接比较 (MAIC)方法论 方法论 方法论方法 方法 方法 方法.网络元分析 (NMA)瘤学 在瘤学方面.系统性文献综述 (SLR) 是一种系统的文献综述.更多相关视频
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