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一种大型良性 adrenocortical 腺瘤共同分泌和皮质醇

Martha Dillon¹, Sara Shteyman¹, Samaneh Rabiehashemi^1,2

¹Division of Endocrinology and Metabolism, University of Connecticut School of Medicine, Farmington, CT 06030, USA.

JCEM case reports

|April 25, 2024

概括

这项案例研究强调了一种罕见的上腺腺瘤共同分泌皮质醇和雄激素,导致库辛综合征和病毒化. 手术去除症状,强调迅速评估上腺质量.

科学领域:

内分泌学在内分泌学.
在瘤学瘤学.

背景情况:

上腺瘤是常见的,通常是良性上腺皮层瘤.
虽然许多是非功能性的,但有些人分泌皮质醇;雄激素或雌激素分泌腺瘤很少见.
共同分泌的上腺体可以呈现复杂的临床情景.

研究的目的:

报告一个44岁的女性患上上腺腺瘤并分泌皮质醇和雄激素的病例.
为了说明这种罕见疾病的临床表现,诊断和管理.
强调迅速评估上腺体质量的重要性,特别是那些共同分泌激素.

主要方法:

一个44岁的女性的病例介绍,她有过高雄性和库辛综合征的症状.
实验室评估包括24小时尿液自由皮质醇,ACTH水平,和androstenedione.
腹部计算机断层扫描 (CT) 用于上腺质量表征.
通过左侧开放性上腺切除术和随后的病理分析进行手术管理.

主要成果:

这位患者出现了,,二次性无精液和体重增加.
实验室结果表明,ACTH独立的库希综合征与皮质醇,和androstenedione的升高.
一个大的左上腺体被确定并通过手术切除.
经过上腺切除术后,患者经历了显著的临床改善,包括过高雄激素和高皮质醇症的解决,血压和葡萄糖水平的正常化.

结论:

上腺腺瘤共同分泌皮质醇和雄激素可以导致诸如库希综合征和病毒化等显著的临床表现.
早期诊断和手术干预对于有利的结果至关重要.
在分泌雄激素的上腺体中,上腺癌 (ACC) 的可能性需要迅速和彻底的调查.

关键词:

库辛综合征是什么意思库辛综合征是什么意思上腺腺瘤腺瘤上皮层癌 (adrenocortical carcinoma) 是一种上皮层癌.过高雄性主义 (hyperandrogenism) 是一种高雄性主义.过高皮质醇主义是什么?病毒化病毒化病毒化

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