Jove
Visualize
联系我们
JoVE
x logofacebook logolinkedin logoyoutube logo
关于 JoVE
概览领导团队博客JoVE 帮助中心
作者
出版流程编辑委员会范围与政策同行评审常见问题投稿
图书馆员
用户评价订阅访问资源图书馆顾问委员会常见问题
研究
JoVE JournalMethods CollectionsJoVE Encyclopedia of Experiments存档
教育
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab Manual教师资源中心教师网站
使用条款与条件
隐私政策
政策

相关概念视频

Cluster Sampling Method01:20

Cluster Sampling Method

11.9K
Appropriate sampling methods ensure that samples are drawn without bias and accurately represent the population. Because measuring the entire population in a study is not practical, researchers use samples to represent the population of interest.
To choose a cluster sample, divide the population into clusters (groups) and then randomly select some of the clusters. All the members from these clusters are in the cluster sample. For example, if you randomly sample four departments from your...
11.9K
Survival Tree01:19

Survival Tree

80
Survival trees are a non-parametric method used in survival analysis to model the relationship between a set of covariates and the time until an event of interest occurs, often referred to as the "time-to-event" or "survival time." This method is particularly useful when dealing with censored data, where the event has not occurred for some individuals by the end of the study period, or when the exact time of the event is unknown.
 Building a Survival Tree
Constructing a...
80
Sampling Plans01:23

Sampling Plans

181
Sampling is a crucial step in analytical chemistry, allowing researchers to collect representative data from a large population. Common sampling methods include random, judgmental, systematic, stratified, and cluster sampling.
Random sampling is a method where each member of the population has an equal chance of being selected for the sample. It involves selecting individuals randomly, often using random number generators or lottery-type methods. For example, when analyzing the properties of a...
181
Evolutionary Relationships through Genome Comparisons02:54

Evolutionary Relationships through Genome Comparisons

5.7K
Genome comparison is one of the excellent ways to interpret the evolutionary relationships between organisms. The basic principle of genome comparison is that if two species share a common feature, it is likely encoded by the DNA sequence conserved between both species. The advent of genome sequencing technologies in the late 20th century enabled scientists to understand the concept of conservation of domains between species and helped them to deduce evolutionary relationships across diverse...
5.7K
Hypothesis Test for Test of Independence01:16

Hypothesis Test for Test of Independence

3.6K
The test of independence is a chi-square-based test used to determine whether two variables or factors are independent or dependent. This hypothesis test is used to examine the independence of the variables. One can construct two qualitative survey questions or experiments based on the variables in a contingency table. The goal is to see if the two variables are unrelated (independent) or related (dependent). The null and alternative hypotheses for this test are:
H0: The two variables (factors)...
3.6K
Statistical Inference Techniques in Hypothesis Testing: Parametric Versus Nonparametric Data01:16

Statistical Inference Techniques in Hypothesis Testing: Parametric Versus Nonparametric Data

124
Statistical inference techniques, paramount in hypothesis testing, differentiate into two broad categories: parametric and nonparametric statistics.
Parametric statistics, as the name suggests, assumes that data follow a specific distribution, often a normal distribution. This assumption enables robust hypothesis testing and estimation. Parametric methods, like the Student's t-test or Goodness-of-fit test, are frequently employed in biostatistics due to their robustness. For instance,...
124

您也可能阅读

相关文章

通过共同作者、期刊和引用图与本文相关的文章。

排序
Same author

Discussion of "Data fission: splitting a single data point".

Journal of the American Statistical Association·2025
Same author

Controlling the False Split Rate in Tree-Based Aggregation.

Journal of the American Statistical Association·2025
Same author

Inferring independent sets of Gaussian variables after thresholding correlations.

Journal of the American Statistical Association·2025
Same author

Generalized data thinning using sufficient statistics.

Journal of the American Statistical Association·2025
Same author

Testing for a difference in means of a single feature after clustering.

Biostatistics (Oxford, England)·2024
Same author

Tree-Values: Selective Inference for Regression Trees.

Journal of machine learning research : JMLR·2024
Same journal

Instrumental Variable Estimation of Marginal Structural Mean Models for Time-Varying Treatment.

Journal of the American Statistical Association·2026
Same journal

Semiparametric Joint Modeling for Survival Analysis with Longitudinal Covariates.

Journal of the American Statistical Association·2026
Same journal

Dimension Reduction for Large-Scale Federated Data: Statistical Rate and Asymptotic Inference.

Journal of the American Statistical Association·2026
Same journal

Facilitating Heterogeneous Effect Estimation via Statistically Efficient Categorical Modifiers.

Journal of the American Statistical Association·2026
Same journal

Nonparametric Density Estimation of a Long-Term Trend from Repeated Semicontinuous Data.

Journal of the American Statistical Association·2026
Same journal

Functional Integrative Bayesian Analysis of High-dimensional Multiplatform Clinicogenomic Data.

Journal of the American Statistical Association·2026
查看所有相关文章

相关实验视频

Updated: Jun 27, 2025

Large-scale Reconstructions and Independent, Unbiased Clustering Based on Morphological Metrics to Classify Neurons in Selective Populations
12:27

Large-scale Reconstructions and Independent, Unbiased Clustering Based on Morphological Metrics to Classify Neurons in Selective Populations

Published on: February 15, 2017

7.0K

对等级集群的选择性推理.

Lucy L Gao1, Jacob Bien2, Daniela Witten3

  • 1Department of Statistics, University of British Columbia.

Journal of the American Statistical Association
|April 25, 2024
PubMed
概括
此摘要是机器生成的。

当通过集群确定群组时,传统的统计测试会增加I型错误率. 本研究引入了一种选择性推断方法,以准确测试群集之间的平均差异,控制基于数据的假设选择.

关键词:
平均水平的差异意味着.假设测试 测试 假设测试选择后的推断推断.一种类型I错误

更多相关视频

A Machine Learning Approach to Design an Efficient Selective Screening of Mild Cognitive Impairment
12:18

A Machine Learning Approach to Design an Efficient Selective Screening of Mild Cognitive Impairment

Published on: January 11, 2020

7.5K
Heuristic Mining of Hierarchical Genotypes and Accessory Genome Loci in Bacterial Populations
08:03

Heuristic Mining of Hierarchical Genotypes and Accessory Genome Loci in Bacterial Populations

Published on: December 7, 2021

2.1K

相关实验视频

Last Updated: Jun 27, 2025

Large-scale Reconstructions and Independent, Unbiased Clustering Based on Morphological Metrics to Classify Neurons in Selective Populations
12:27

Large-scale Reconstructions and Independent, Unbiased Clustering Based on Morphological Metrics to Classify Neurons in Selective Populations

Published on: February 15, 2017

7.0K
A Machine Learning Approach to Design an Efficient Selective Screening of Mild Cognitive Impairment
12:18

A Machine Learning Approach to Design an Efficient Selective Screening of Mild Cognitive Impairment

Published on: January 11, 2020

7.5K
Heuristic Mining of Hierarchical Genotypes and Accessory Genome Loci in Bacterial Populations
08:03

Heuristic Mining of Hierarchical Genotypes and Accessory Genome Loci in Bacterial Populations

Published on: December 7, 2021

2.1K

科学领域:

  • 统计方法学的统计方法.
  • 生物信息学是一种生物信息学.
  • 数据科学是数据科学.

背景情况:

  • 经典的统计测试假设组是先验定义的.
  • 基于集群的组定义导致传统测试的I型错误率膨胀.
  • 这一问题即使在独立的数据集中继续存在,用于集群和测试.

研究的目的:

  • 开发一种选择性推断方法来测试两个集群之间的平均差异.
  • 控制类型I错误率,当假设是数据驱动的.
  • 提供一种有效的方法来计算等级聚类的确切p值.

主要方法:

  • 提出了一种选择性推断程序,以解决膨胀的I型错误.
  • 开发了精确的p值的高效计算,用于聚合层次的分类.
  • 使用模拟和单细胞RNA测序数据验证了该方法.

主要成果:

  • 提出的选择性推断方法有效控制了I型错误率.
  • 在数据驱动的集群比较中证明了准确的p值计算.
  • 成功地将该方法应用于现实世界单细胞RNA测序数据.

结论:

  • 在数据驱动集群后,选择性推断对于有效的假设测试至关重要.
  • 开发的方法提供了一个统计学上合理的方法来比较群集之间的平均值.
  • 这项工作对利用聚类的领域有影响,例如单细胞基因组学.